Evidence map›Paper›PMID 42021327›Full record

ArticleJournal of cardiothoracic surgery2026

SMARCA4-deficient thoracic tumor with vascular differentiation requiring superior vena cava reconstruction: a case report.

June Yao, Shaira Gail Santos, Mark Fowler, Jennifer Wan

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

June YaoDepartment of Surgery, Community Memorial Hospital, Ventura, CA, USA.
Shaira Gail SantosCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA. shairagail.santos@westernu.edu.
Mark FowlerDepartment of Pathology, Community Memorial Hospital, Ventura, CA, USA.
Jennifer WanDepartment of Surgery, Community Memorial Hospital, Ventura, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSMARCA4-deficient tumors are rare, highly aggressive malignancies characterized by inactivation of the SMARCA4 gene, most frequently observed in male smokers. CASE PRESENTATION: We report an unusual case of a SMARCA4-deficient tumor with vascular differentiation in a 54-year-old non-smoking Asian female with a right paratracheal mass invading the superior vena cava (SVC). Final pathology confirmed a SMARCA4-deficient neoplasm with strong vascular markers on immunohistochemical staining. The patient underwent staged surgical management, including en bloc resection of the mass and SVC with complex vascular reconstruction using a bifurcated graft.

conclusionsThis case illustrates the diagnostic complexity of SMARCA4-deficient tumors and highlights an unusual clinical and pathological presentation.

Indexed as

DNA HelicasesNuclear ProteinsPlastic Surgery ProceduresThoracic NeoplasmsTranscription FactorsVena Cava, SuperiorFemaleHumansMiddle AgedDNA HelicasesNuclear ProteinsSMARCA4 protein, humanTranscription FactorsSMARCA4-deficient tumorSuperior vena cava reconstructionVascular differentiation

Identifiers

PMID42021327
PMCPMC13251144

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.