Trial reportBMC oral health2026
Open flap debridement with EDTA-conditioned root surface biomodification with or without injectable platelet-rich fibrin: a randomized controlled trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07207668 (Effectiveness of Injectable Platelet Rich Fibrin Used For Root Surface Biomodification On Clinical Periodontal Parameters), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Injectable Platelet Rich Fibrin Used For Root Surface Biomodification On Clinical Periodontal Parameters
Who cites it
0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis randomized controlled clinical trial evaluated the incremental clinical effect of adjunctive injectable platelet-rich fibrin (i-PRF) when added to open flap debridement (OFD) with 24% EDTA root surface conditioning. MATERIALS AND
methodsA total of 42 individuals diagnosed with Stage II–IV periodontitis and presenting with at least three adjacent teeth with probing pocket depth (PPD) ≥ 5 mm were enrolled. Participants were randomly allocated into two equal groups. Both groups underwent OFD combined with 24% EDTA root surface conditioning, and the test group additionally received a 5-min application of i-PRF. Clinical periodontal parameters, including plaque index (PI), gingival index (GI), bleeding on probing (BOP), gingival recession width (GRW), gingival recession depth (GRD), probing pocket depth (PPD), and clinical attachment level (CAL), were recorded using a calibrated periodontal probe under standardized conditions.
resultsBoth groups demonstrated comparable improvements in PI, GI, BOP, GRW, and GRD (p > 0.05). At the 180-day follow-up, the test group exhibited significantly greater PPD reduction and greater CAL gain than the control group (p < 0.001 and p < 0.05, respectively). At surgically treated sites, the additional 6-month improvement in the test group was 1.02 mm for PPD and 1.14 mm for CAL. Postoperative pain and sensitivity scores remained low in both groups, and no clinically relevant intergroup differences in biocompatibility or soft-tissue healing were observed.
conclusionAdjunctive use of i-PRF within an EDTA-conditioned OFD protocol resulted in more favorable early clinical healing outcomes, particularly with respect to PPD reduction and CAL gain, compared with OFD + EDTA alone. These findings suggest that injectable platelet concentrates may serve as a useful adjunct for improving early clinical outcomes following periodontal surgery.
trial registrationClinicalTrials.gov Identifier: NCT07207668. Retrospectively registered on September 18,2025.
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