ArticleBMC palliative care2026
The LiverCare intervention: implementing structured palliative care in hepatology - a multicenter mixed-methods feasibility study in patients with cirrhosis.
Article in BMC palliative care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05431946 (Palliative Care for Patients With Liver Cirrhosis - a Multicentre Intervention Study), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Palliative Care for Patients With Liver Cirrhosis - a Multicentre Intervention Study
Who cites it
1 citing paper in PubMed.
- Palliative Care in Patients with Liver Cirrhosis: A Scoping Review of Identification, Interventions, and Implementation Barriers and Facilitators.Healthcare (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver cirrhosis is associated with high symptom burden, psychological distress, and substantial unmet supportive care needs. Although early palliative care improves outcomes in other serious diseases, it remains under integrated in hepatology. This study evaluated the feasibility of a structured palliative care intervention for patients with cirrhosis and their informal caregivers.
methodsLiverCare is a multicenter, mixed-methods feasibility study conducted across four Danish hepatology departments. Eligible patients were identified using the Supportive and Palliative Care Indicators Tool. The intervention comprised structured, repeated palliative care conversations delivered by trained hepatologists and liver nurse specialists alongside routine clinical care. Between August 2023 and July 2024, 42 patients and 25 informal caregivers were enrolled. Outcomes included anxiety, depression, quality of life, caregiver burden, and qualitative interviews. Feasibility was evaluated using the RE-AIM framework.
resultsOf 68 eligible patients, 42 were enrolled (62%). All completed the first conversation; 27 and 12 completed the second and third conversations, respectively. Patient-reported outcomes on anxiety, depression, and quality of life remained stable during follow-up. Caregiver burden decreased over time. Qualitative findings demonstrated enhanced communication, emotional validation, and facilitated future care planning. Across all conversations, 128 clinical actions were initiated. The intervention was delivered with high fidelity and was perceived as relevant and meaningful.
conclusionsStructured palliative care integrated within hepatology was feasible and acceptable and was associated with reduced caregiver burden. These findings support further evaluation in a larger controlled study and inform implementation of palliative care in advanced liver disease.
trial registrationClinicalTrials.gov NCT05431946, registered 24 June 2022.
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