Evidence map›Paper›PMID 42021205›Full record

ArticleBMC medical imaging2026

Reduced right/left ventricular blood pool T2 ratio on cardiac magnetic resonance indicates cognitive impairment in heart failure secondary to ischemic heart disease.

Yadong Cui, Chong Zheng, Shanshan Gu, Jin Si, Keling Xiao, Yujie Hu, Yang Yang, Jing Li, Jie Lu

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In one paragraph

Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yadong Cui *Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Chong Zheng *Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Shanshan GuDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Jin SiDepartment of Geriatrics, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University, Beijing, China.
Keling XiaoDepartment of Geriatrics, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University, Beijing, China.
Yujie HuCentral Research Institute, United Imaging Healthcare Group, Shanghai, China.
Yang YangBeijing United Imaging Research Institute of Intelligent Imaging, Beijing, China.
Jing LiDepartment of Geriatrics, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University, Beijing, China.
Jie LuDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China. imaginglu@hotmail.com.

Funding

Beijing Natural Science Foundation L252091Project of Xuanwu Hospital QNPY202430
6 · The paper itself

Abstract

purposeThe right-to-left ventricular blood pool T2 ratio (RV/LV T2 ratio) derived from cardiac magnetic resonance (CMR) T2 mapping is a potential biomarker of blood oxygenation. This study investigated the association between RV/LV T2 ratio and cognitive performance in heart failure (HF) secondary to ischemic heart disease (IHD).

methodsThis retrospective study included 52 patients with chronic HF and 26 healthy controls, all of whom underwent CMR and neuropsychological testing. Regions of interest were manually drawn in RV and LV blood pools to calculate RV/LV T2 ratio. Cognitive performance was assessed by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Group comparisons and linear, multivariate, and mediation analyses were performed.

resultsHC demonstrated higher RV/LV T2 ratio than patients with HF with preserved or reduced and mildly reduced ejection fraction (p = 0.012, and p < 0.001). Patients with cognitive impairment (MoCA-defined) showed lower RV/LV T2 ratios than cognitively normal patients (p = 0.010). RV/LV T2 ratio was positively related to MMSE (β = 0.336, p = 0.020) and MoCA score (β = 0.563, p < 0.001). In multivariate linear regression analysis, RV/LV T2 ratio was the only CMR predictor for MoCA score (β = 0.340, p = 0.015). Mediation analysis showed RV/LV T2 ratio partially mediated the correlation between stroke volume and MoCA score, with a mediation effect ratio of 44.3%.

conclusionRV/LV T2 ratio is an additional CMR biomarker to evaluate the cognitive performance in patients with HF secondary to IHD.

Indexed as

Cognitive DysfunctionHeart FailureHeart VentriclesMagnetic Resonance ImagingMyocardial IschemiaAgedFemaleHumansMagnetic Resonance Imaging, CineMaleMiddle AgedNeuropsychological TestsRetrospective StudiesStroke VolumeCardiac magnetic resonanceCognitive impairmentHeart failureT2 mapping

Identifiers

PMID42021205
PMCPMC13235024

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