ArticleBMC pregnancy and childbirth2026
Abnormal renal function three months after delivery among pre-eclampsia survivors in Sub-Saharan Africa: a prospective cohort study in Uganda.
Article in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
backgroundPre-eclampsia, a significant contributor to maternal and newborn mortality and morbidity, is a common pregnancy-specific hypertensive disorder that affects multiple systems, including the renal system. The consequences of pre-eclampsia on the survivors’ kidneys may result in abnormal renal function post-delivery, ultimately leading to the onset of chronic kidney disease. Despite pre-eclampsia being very common in women of African ancestry, there are hardly any studies that have investigated its long-term consequences in women of sub-Saharan Africa. This study aimed to establish the incidence and factors associated with abnormal renal function three months after delivery among pre-eclampsia survivors in a peri-urban Ugandan setting.
methodsBetween November 2018 and June 2019, we recruited a prospective cohort of 116 women who experienced pre-eclampsia. Clinical and laboratory information were gathered at both delivery and three months postpartum. The incidence of abnormal renal function among pre-eclampsia survivors was assessed based on those with an estimated glomerular filtration rate < 90 ml/min/1.73 m², determined using the CKD-EPI equation. Multivariate modified Poisson regression with robust standard errors was conducted to identify factors associated with abnormal renal function.
resultsA high incidence of abnormal renal function, amounting to 16.7%, was observed. The delivery of a male baby (aRR 4.404; 95% CI 1.436–13.504, p-value = 0.010) and the persistence of hypertension three months after delivery (aRR 2.849; 95% CI 1.067–7.601, p-value = 0.037) were independently associated with abnormal renal function three months post-delivery.
conclusionsA substantial proportion of women exhibit abnormal renal function three months following a pregnancy complicated by pre-eclampsia. It is imperative to prioritize long-term follow-up for survivors of pre-eclampsia in low- and middle-income settings, mirroring the attention given in high-income settings. This emphasis is essential for the prevention, early detection, and timely intervention in addressing chronic renal disease.
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