ArticleBMC genomics2026
Comparative mitochondrial genome analyses of five medicinal mushroom Sanghuangporus provide insights into conservation, variation, and phylogenetic relationships.
Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundSanghuangporus species are white-rot basidiomycetes of notable ecological and economic importance, playing critical roles in wood decomposition and medicinal applications. However, comprehensive genus-level mitochondrial genome analyses for Sanghuangporus remain limited, which constrains understanding of mitochondrial genome evolution within this lineage.
resultsThe second- and third-generation sequencing alongside comparative genomic approaches, we analyzed the mitochondrial genomes of five Sanghuangporus species (S. weigelae, S. lonicericola, S. alpinus, S. sanghuang, and S. vaninii). Genome sizes ranged from 97,345 to 116,792 bp, with GC contents between 23.21% and 24.04%. Comparative analyses revealed that mitochondrial genome expansion within the Hymenochaetaceae is primarily driven by intron gain. While core protein-coding genes (PCGs) have remained largely conserved, rearrangements were detected in intergenic regions, highlighting the dynamic structural evolution of these fungal mitochondrial genomes. Phylogenetic analyses based on concatenated PCGs and cox1 robustly resolved Sanghuangporus as a monophyletic clade. Among the conserved PCGs, atp9 and nad4L exhibited the lowest genetic divergence, all genes displayed Ka/Ks ratios < 1, indicating that they were under pervasive purifying selection. Repeat contents, nucleotide diversity, codon usage bias, tRNA secondary structures, and RNA-editing patterns were also characterized.
conclusionThis study provides the first genus-level comprehensive mitochondrial genomic framework for Sanghuangporus, illustrating how fungal mitochondrial genomes evolve through intron-mediated expansion, structural rearrangement, and strong functional constraint. Our findings broadly contribute to the understanding of mitochondrial genome evolution in fungi and provide a valuable resource for evolutionary, ecological, and biotechnological studies of medicinally important species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.