Evidence map›Paper›PMID 42021123›Full record

ArticleGut microbes2026

Han Chen, Yan Wang, Zizhuang Wang, Wei Su, Yuting Shao, Guoxin Zhang, Zi Wang, Yixin Ge, Xiaoying Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Han ChenDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Yan WangDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Zizhuang WangDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Wei SuDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Yuting ShaoDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Guoxin ZhangDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Zi WangDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Yixin GeHuadong Research Institute for Medicine and Biotechniques, Nanjing, China.
Xiaoying ZhouDepartment of Gastroenterology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.ORCID 0000-0002-6529-0243

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetabolic reprogramming and epigenetic alterations play important roles in driving tumor microenvironment (TME) remodeling and immune evasion in gastric cancer (GC). Histone lactylation links glycolytic metabolism to transcriptional regulation, but its role in

methodsMultiomics analysis (ChIP-seq and RNA-seq) with

resultsHistone lactylation, specifically H3K18la, was significantly elevated in GC tissues and further elevated upon

conclusions

Indexed as

B7-H1 AntigenHelicobacter InfectionsHelicobacter pyloriHistonesImmune EvasionProto-Oncogene Proteins c-mycStomach NeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorDisease ProgressionGlycolysisHumansMiceSignal TransductionTumor MicroenvironmentB7-H1 AntigenCD274 protein, humanHistonesMYC protein, humanProto-Oncogene Proteins c-mycgastric cancerHelicobacter pylorihistone lactylationhyaluronan synthase 2immune evasion

Identifiers

PMID42021123
PMCPMC13108356

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.