Evidence map›Paper›PMID 42020918›Full record

ArticleGeroScience2026

Prediction of cognitive test scores: a comparison of brain structure, health, demographic, and cognitive data across adulthood.

Camilla Mendl-Heinisch, Nora Bittner, Tatiana Miller, Paulo Dellani, Fabian Bamberg, Klaus Berger, Patricia Bohmann, Josua A Decker, Agnes Flöel, Karin Halina Greiser and 18 more

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Camilla Mendl-HeinischInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Nora BittnerInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Tatiana MillerInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Paulo DellaniInstitute for Anatomy I, Medical Faculty & University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Fabian BambergDepartment of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Faculty of Medicine - University of Freiburg, Freiburg, Germany.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Patricia BohmannDepartment of Preventive Medicine and Epidemiology, University of Regensburg, Regensburg, Germany.
Josua A DeckerDepartment of Diagnostic and Interventional Radiology, University Hospital Augsburg, Augsburg, Germany.
Agnes FlöelDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Karin Halina GreiserDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany.
Manuela HarriesDepartment of Epidemiology, Helmholtz Centre for Infection Research, Brunswick, Germany.
Jan KaparLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Thomas KeilInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Carolina J Klett-TammenDepartment of Epidemiology, Helmholtz Centre for Infection Research, Brunswick, Germany.
Lilian KristInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Thomas KrönckeDepartment of Diagnostic and Interventional Radiology, University Hospital Augsburg, Augsburg, Germany.
Michael LeitzmannDepartment of Preventive Medicine and Epidemiology, University of Regensburg, Regensburg, Germany.
Thoralf NiendorfBerlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Tobias PischonMax Delbrück- Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.
Oliver RiedelLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Steffen RinghofDepartment of Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Christopher L SchlettDepartment of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Faculty of Medicine - University of Freiburg, Freiburg, Germany.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany.
Mark O WielpützDepartment of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Kerstin WirknerLeipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig, Germany.
Svenja CaspersInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Christiane JockwitzInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany. c.jockwitz@fz-juelich.de.ORCID http://orcid.org/0000-0001-9332-7982

Funding

European Union's Horizon Europe research and innovation programme 101147319Federal Ministry of Research, Technology and Space (BMFTR) 01ER1301A/B/CFederal Ministry of Research, Technology and Space (BMFTR) 01ER1511DFederal Ministry of Research, Technology and Space (BMFTR) 01ER1801A/B/C/DFederal Ministry of Research, Technology and Space (BMFTR) 01ER2301A/B/C
6 · The paper itself

Abstract

Cognitive performance prediction may help identify early cognitive decline. However, the heterogeneity of research findings impedes the identification of key predictors. This study used 21,877 participants (25-74 years) from the German National Cohort (NAKO Gesundheitsstudie, NAKO) to systematically predict cognitive test scores based on brain structure, demographic, health-related, and cognitive data. Importantly, validation analyses were performed across study sites and external samples (1000BRAINS). Higher predictability was observed in the total sample compared to age-specific subgroups (10% difference in explained variance). Demographic (e.g. age) and cognitive data (e.g. memory) outperformed brain structure (e.g. grey matter volume) and health-related data (e.g. hypertension). Cognitive tests were differentially predictable, most evident between episodic memory and motor speed (R

Indexed as

Age decadesBrain structureCognitive functionsDemographicHealth-relatedMachine learning analysesPrediction

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.