ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Nurse-led remote symptom management for chemotherapy toxicity and quality of life in lymphoma: a quasi-experimental study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChemotherapy for lymphoma often induces distressing toxicities that impair treatment adherence and quality of life (QoL). With increasing demand for decentralized cancer care, nurse-led telehealth interventions offer a promising approach to support symptom management.
objectiveThis study aimed to evaluate the effectiveness of a nurse-led remote symptom management model in reducing chemotherapy-related toxicities and improving QoL among patients with newly diagnosed lymphoma in China.
methodsA quasi-experimental study was conducted in a tertiary oncology center. Patients newly diagnosed with lymphoma and undergoing ≥ 6 cycles of chemotherapy were enrolled between July 2022 and December 2023. Participants receiving care between July 2022 and June 2023 formed the intervention group (N = 286), while those from July to December 2023 constituted the control group (N = 143). The intervention comprised structured telephone follow-ups by oncology nurses using CTCAE v5.0 criteria and a graded management protocol. Primary outcomes were incidences of grade ≥ 2 toxicities. Secondary outcomes included changes in QoL measured by the EORTC QLQ-C30. Generalized estimating equations (GEE) were used to analyze longitudinal data.
resultsCompared to the control group, the intervention group demonstrated significantly lower odds of fatigue (OR = 0.62), nausea (OR = 0.56), vomiting (OR = 0.34), and constipation (OR = 0.30; all P < 0.01). No significant differences were observed for diarrhea, fever, or pain. QoL analysis showed improvements in global health status (β = 3.73), social functioning (β = 6.02), and financial difficulties (β = -6.07).
conclusionNurse-led remote symptom management significantly reduced core chemotherapy-related toxicities and enhanced QoL in patients with lymphoma. These findings support the integration of structured remote symptom management into oncology care models in resource-constrained settings.
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