Evidence map›Paper›PMID 42020793›Full record

ArticleCommunications biology2026

Exploring bone formation mechanism and pattern during RANKL inhibition in a fibrous dysplasia mouse model.

Giorgia Farinacci, Ilenia Coletta, Biagio Palmisano, Emanuela Spica, Chiara Tavanti, Samuele Di Cristofano, Samantha Donsante, Marta Serafini, Tiziana Borsello, Mary Anna Venneri and 6 more

Abstract read
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In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Giorgia FarinacciDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0003-0122-0155
Ilenia ColettaIRCCS Neuromed, Pozzilli (IS), Italy.
Biagio PalmisanoDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-1287-5256
Emanuela SpicaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Chiara TavantiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Samuele Di CristofanoDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy.
Samantha DonsanteTettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.ORCID http://orcid.org/0000-0001-6970-758X
Marta SerafiniTettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Tiziana BorselloDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
Mary Anna VenneriDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Alessandro CorsiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-6896-4509
Debora SalernoDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Benedetta DonatiLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Alessia CiarrocchiLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Domenico RaimondoDepartment of Molecular Medicine, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur-Fondazione Cenci Bolognetti, Rome, Italy.ORCID http://orcid.org/0000-0002-1780-7295
Mara RiminucciDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy. mara.riminucci@uniroma1.it.ORCID http://orcid.org/0000-0002-8643-9211

Funding

Sapienza Università di Roma (Sapienza University of Rome) RP124190960A2E07
6 · The paper itself

Abstract

Fibrous dysplasia (FD) of bone is a fibro-osseous disorder caused by GNAS mutations with defective osteogenic differentiation and increased bone remodeling activity. Inhibition of RANKL leads to the replacement of FD lesions with bone. However, the mechanism and pattern of deposition of the newly formed bone remain unclear. Here, we perform morphological and molecular analyses on EF1α-Gsα

Indexed as

Fibrous Dysplasia of BoneOsteogenesisRANK LigandAnimalsCell DifferentiationDisease Models, AnimalMiceOsteoblastsRANK LigandTnfsf11 protein, mouse

Identifiers

PMID42020793
PMCPMC13463084

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.