Evidence map›Paper›PMID 42020745›Full record

ArticleNature2026

Myosin forces remodel F-actin for mechanosensitive protein recognition.

Ayala G Carl, Matthew J Reynolds, Xiaoyu Sun, Pinar S Gurel, Donovan Y Z Phua, Keith Hamilton, Lin Mei, John W Watters, Yasuharu Takagi, Alex J Noble and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ayala G Carl *Laboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.
Matthew J Reynolds *Laboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.
Xiaoyu Sun *Laboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.
Pinar S GurelLaboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.
Donovan Y Z PhuaLaboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.
Keith HamiltonLaboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.
Lin MeiLaboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-5056-4547
John W WattersLaboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.
Yasuharu TakagiLaboratory of Molecular Physiology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Alex J NobleSimons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-8634-2279
James R SellersLaboratory of Molecular Physiology, Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Gregory M AlushinLaboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA. galushin@rockefeller.edu.ORCID http://orcid.org/0000-0001-7250-4484

Funding

Mechanosensing Via Cytoskeletal StrainDP5OD017885 · OD · ROCKEFELLER UNIVERSITY · PI ALUSHIN, GREGORY M · 2016 to 2019
$1.7M
Structural Mechanisms of Cytoskeletal Force-SensingR01GM141044 · NIGMS · ROCKEFELLER UNIVERSITY · PI ALUSHIN, GREGORY M · 2021 to 2024
$1.5M
Studies Of Myosin VZ01HL004229 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SELLERS, JAMES R. · 1997 to 2008
$1.1M
Tri-Institutional PhD Program in Chemical BiologyT32GM115327 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TAN, DEREK S · 2015 to 2019
$741k
MAKAP FUNCTIONS OF A PKA ANCHORING PROTEINK08HL004229 · NHLBI · OREGON HEALTH AND SCIENCE UNIVERSITY · PI KAPILOFF, MICHAEL SETH · 2000 to 2004
$635k
Structural Studies of Type II Cadherins on Membranes by Cryo-Electron TomographyF32GM128303 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI NOBLE, ALEX JAMES · 2018 to 2019
$120k
Structural and Molecular Mechanisms of Stress Fiber RepairF31HL165906 · NHLBI · ROCKEFELLER UNIVERSITY · PI PHUA, DONOVAN YONG ZHI · 2022 to 2023
$94k
Intramural NIH HHS Z01 HL004229NHLBI NIH HHS F31 HL165906NHLBI NIH HHS K08 HL004229NIGMS NIH HHS F32 GM128303NIGMS NIH HHS R01 GM141044NIGMS NIH HHS T32 GM115327NIH HHS DP5 OD017885
6 · The paper itself

Abstract

Cells interface mechanically with their surroundings through cytoskeleton-linked adhesions

Indexed as

ActinsMechanotransduction, CellularMyosinsActin Cytoskeletonalpha CateninAnimalsCryoelectron MicroscopyHumansModels, MolecularProtein BindingActinsalpha CateninMyosins

Identifiers

PMID42020745
PMCPMC13233326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.