Evidence map›Paper›PMID 42020738›Full record

ArticleNature2026

Astrocytes connect specific brain regions through plastic networks.

Melissa L Cooper, Maria Clara Selles, Michael Cammer, Chase Redd, Holly K Gildea, Joseph Sall, Katelyn E Chiurri, Philip Cheung, Damian G Wheeler, Aiman S Saab and 2 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Striatal cholinergic and dopaminergic driven astrocyte CabioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Neuroinflammation in glaucoma: a myriad of cellular pathways and players.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  9. Article
  10. Physical contact reveals a hidden layer of cortical architecture.bioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Melissa L CooperInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY, USA. melissa.cooper@nyulangone.org.ORCID http://orcid.org/0000-0003-4337-8356
Maria Clara SellesInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY, USA.
Michael CammerMicroscopy Laboratory, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-4930-1739
Chase ReddTranslucence Biosystems, Irvine, CA, USA.
Holly K GildeaInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-9549-890X
Joseph SallMicroscopy Laboratory, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-8585-175X
Katelyn E ChiurriInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0009-0006-8275-2223
Philip CheungTranslucence Biosystems, Irvine, CA, USA.
Damian G WheelerTranslucence Biosystems, Irvine, CA, USA.
Aiman S SaabInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-3886-8369
Shane A LiddelowInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY, USA. shane.liddelow@nyulangone.org.ORCID http://orcid.org/0000-0002-0840-1437
Moses V ChaoInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York, NY, USA. moses.chao@nyulangone.org.ORCID http://orcid.org/0009-0003-2984-5138

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RICHARD W TSIEN · 2018 to 2026
$36.4M
Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Yongzhao Shao · 2020 to 2026
$28.4M
Training Systems and Integrative NeuroscienceT32MH019524 · NIMH · NEW YORK UNIVERSITY · PI KIORPES, LYNNE · 1992 to 2025
$5.2M
Neurotoxicity of Reactive Astrocyte-secreted Lipids in Neurodegenerative DiseaseR01EY033353 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Shane Liddelow · 2022 to 2026
$2.5M
The role of glia in monitoring neuronal proteostasis in agingK00AG068343 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GILDEA, HOLLY KATHERINE · 2022 to 2025
$338k
Astrocyte Network Facilitation of NeuroplasticityK99NS139313 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Melissa L Cooper · 2025 to 2026
$282k
NCI NIH HHS P30 CA016087NEI NIH HHS R01 EY033353NIA NIH HHS K00 AG068343NIA NIH HHS P30 AG066512NIMH NIH HHS T32 MH019524NINDS NIH HHS K99 NS139313NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

Neuronal axons have traditionally been considered to be the primary mediators of functional connectivity among brain regions. However, the role of astrocyte-mediated communication has been largely underappreciated. Astrocytes communicate with one another through gap junctions, but the extent and specificity of this communication remain poorly understood. Astrocyte gap junctions are necessary for memory formation

Indexed as

AstrocytesBrainNerve NetNeuronal PlasticityAnimalsFemaleGap JunctionsMaleMiceMice, Inbred C57BL

Identifiers

PMID42020738
PMCPMC13322983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.