Evidence map›Paper›PMID 42020733›Full record

ArticleNature2026

Glycerol-driven TNAP activation in thermogenesis and mineralization.

Mohammed Faiz Hussain, Shreya S Krishnan, Brittany L Carroll, Bozena Samborska, Aisha Mousa, Alice Williamson, Maria Delgado-Martin, Bindu Y Srinivasu, Jakub Bunk, Janane F Rahbani and 18 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. An RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Mohammed Faiz Hussain *Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0006-9573-1069
Shreya S Krishnan *Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
Brittany L Carroll *Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
Bozena SamborskaRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Aisha MousaFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Quebec, Canada.
Alice WilliamsonPrecision Healthcare University Research Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-7599-9301
Maria Delgado-MartinRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Bindu Y SrinivasuComputational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin, Berlin, Germany.
Jakub BunkRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Janane F RahbaniRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-4598-4683
Abel OppongRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Anna RoeslerRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Zafir KaiserRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Mina ErsinRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Qiaoqiao ZhangRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Maria Guerra MartinezRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Abhirup ShawRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-3390-3364
Jonathan ChengDepartment of Biochemistry, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0001-7611-7801
Hannah KlemetsDepartment of Biochemistry, McGill University, Montreal, Quebec, Canada.
Katalin Kocsis IllesDepartment of Biochemistry, McGill University, Montreal, Quebec, Canada.
Victoria E DeMambroMaine Health Institute for Research, Scarborough, ME, USA.
Clifford J RosenMaine Health Institute for Research, Scarborough, ME, USA.
José Luis MillánSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1547-2671
Thomas E WalesDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6133-5689
Claudia LangenbergPrecision Healthcare University Research Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-5017-7344
Marc D McKeeCentre de Recherche en Biologie Structurale, McGill University, Montreal, Quebec, Canada.
Alba GuarnéDepartment of Biochemistry, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-4906-9132
Lawrence KazakRosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. lawrence.kazak@mcgill.ca.ORCID http://orcid.org/0000-0002-7591-2544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue-nonspecific alkaline phosphatase (TNAP) promotes skeletal mineralization by hydrolysing pyrophosphate

Indexed as

Alkaline PhosphataseCalcification, PhysiologicGlycerolThermogenesisAllosteric RegulationAnimalsCatalytic DomainEnzyme ActivationHumansMiceModels, MolecularMutation, MissenseOsteoblastsUncoupling Protein 1Alkaline PhosphataseALPL protein, humanGlycerolUncoupling Protein 1

Identifiers

PMID42020733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.