Trial reportNature2026
Multicentre gene therapy for OTOF-related deafness followed up to 2.5 years.
Abstract readMulticenter StudyClinical Trial
In one paragraph
Trial report in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- From cellular regeneration toward functional integration: a 15-year bibliometric analysis of inner ear hair cell regeneration (2011-2025).Frontiers in cellular neuroscience · 2026Pooled it
- Article
- Review
- A single-nucleus transcriptomic atlas of human inner ear development.Nature neuroscience · 2026Article
- Reprogramming translation for rare disease therapy: challenges posed by large genes.Signal transduction and targeted therapy · 2026Article
- Mapping the global trends and hotspots of research on gene therapy and hair cell regeneration for hearing loss: a comprehensive data-mining-based study.Gene therapy · 2026Article
- Dysregulated adult hippocampal neurogenesis in major depressive disorder.Nature medicine · 2026Article
- Intracellular protein binders for imaging, control and future therapeutics.Nature biomedical engineering · 2026Review
- Re-administration of AAV-mediated gene therapy for OTOF-related deafness: a single-arm trial.Nature medicine · 2026Article
- A second chance for gene therapy to restore natural hearing.Nature medicine · 2026Article
- Sound effects: paradigm gene therapy approach installs hearing in children and adolescents born deaf.Signal transduction and targeted therapy · 2026Article
- Pharmacotherapeutic Interventions for Sensorineural Hearing Loss: A Scoping Review.Audiology research · 2026Review
- Engineered Inner Ear Drug Delivery Systems for Hearing Loss Treatment.Research (Washington, D.C.) · 2026Review
- Long-read sequencing and next-generation CRISPR editors: a unified pipeline for rare disease precision medicine with ethical and regulatory perspectives.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors.
Luoying Jiang *ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Xiaoting Cheng *ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Jun Lv *ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Yuxin Chen *ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0004-6241-6535
Xiaoyun Chen *ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-8141-4592
Rongqun Zhai *First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Liqin Zhang *Department of Otorhinolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lei HanENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Yiling ZhangDepartment of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Juhong ZhangChongqing General Hospital (Affiliated Hospital of Chongqing University), Chongqing, China.
Di DengDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Zhicheng HuangDepartment of Otorhinolaryngology, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Qi CaoENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Xin ZhangENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Daqi WangENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Yizhe WangENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Liheng ChenENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Sha YuENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Luo GuoENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Bowen ZhangENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Hui WangENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Yi ZhouDepartment of Otorhinolaryngology, First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Liling DaiENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Wei WangENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Longlong ZhangENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Yanbo YinENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Guiqing ChengENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Ziyi ZhouDepartment of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Wuqing WangENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Bing ChenENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Wei LuFirst Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hongqun JiangDepartment of Otolaryngology, Head and Neck Surgery, First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Zhiqiang GaoDepartment of Otorhinolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Dazhi ShiDepartment of Otorhinolaryngology, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China. dazhi_shi@usc.edu.cn.ORCID http://orcid.org/0000-0002-7928-0388
Yuanping XiongDepartment of Otolaryngology, Head and Neck Surgery, First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. yuanping_xiong@163.com.ORCID http://orcid.org/0000-0001-7317-0295
Yu ZhaoDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China. yuzhao@wchscu.cn.ORCID http://orcid.org/0000-0003-1874-908X
Wei YuanChongqing General Hospital (Affiliated Hospital of Chongqing University), Chongqing, China. weiyuan175@sina.com.
Qin WangDepartment of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha, China. 505027@csu.edu.cn.ORCID http://orcid.org/0000-0001-7603-7166
Guodong FengDepartment of Otorhinolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. fengguodong2013@163.com.ORCID http://orcid.org/0000-0002-3622-5848
Huawei LiENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China. hwli@shmu.edu.cn.ORCID http://orcid.org/0000-0001-5338-6910
Zheng-Yi ChenDepartment of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Technology and Program in Neuroscience, Harvard Medical School, Boston, Ma, USA. zheng-yi_chen@meei.harvard.edu.ORCID http://orcid.org/0000-0002-1452-4193
Yilai ShuENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China. yilai_shu@fudan.edu.cn.ORCID http://orcid.org/0000-0001-8893-434X
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autosomal recessive deafness 9, caused by OTOF gene mutations, is characterized by severe-to-complete congenital deafness
Indexed as
DeafnessGenetic TherapyMembrane ProteinsAdolescentAdultAuditory AcuityChildChild, PreschoolDependovirusEvoked Potentials, Auditory, Brain StemFemaleFollow-Up StudiesGene Therapy AgentsGenetic VectorsHearingHumansMembrane Proteins
Identifiers
PMID
42020731What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.