Evidence map›Paper›PMID 42020714›Full record

ArticleScientific reports2026

Vaginal microbiota composition in pregnant women following cervical conization and radical trachelectomy.

Keita Hasegawa, Yoshifumi Kasuga, Eriko Ohnishi, Kazuhiko Nakabayashi, Hiromi Kamura, Toshimitsu Otani, Satoru Ikenoue, Kenichiro Hata, Mamoru Tanaka

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keita Hasegawa *Department of Obstetrics and Gynecology, Keio University School of Medicine, 35, Shinanomachi, Sinjuku-ku, Tokyo, 160-8582, Japan.
Yoshifumi KasugaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, 35, Shinanomachi, Sinjuku-ku, Tokyo, 160-8582, Japan. kasuga@keio.jp.
Eriko Ohnishi *Department of Maternal-Fetal Biology, National Center for Child Health and Development, Setagaya, Tokyo, 157-8535, Japan.
Kazuhiko NakabayashiDepartment of Maternal-Fetal Biology, National Center for Child Health and Development, Setagaya, Tokyo, 157-8535, Japan.
Hiromi KamuraDepartment of Maternal-Fetal Biology, National Center for Child Health and Development, Setagaya, Tokyo, 157-8535, Japan.
Toshimitsu OtaniDepartment of Obstetrics and Gynecology, Keio University School of Medicine, 35, Shinanomachi, Sinjuku-ku, Tokyo, 160-8582, Japan.
Satoru IkenoueDepartment of Obstetrics and Gynecology, Keio University School of Medicine, 35, Shinanomachi, Sinjuku-ku, Tokyo, 160-8582, Japan.
Kenichiro HataDepartment of Maternal-Fetal Biology, National Center for Child Health and Development, Setagaya, Tokyo, 157-8535, Japan.
Mamoru TanakaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, 35, Shinanomachi, Sinjuku-ku, Tokyo, 160-8582, Japan.

Funding

KAKENHI 20K18173
6 · The paper itself

Abstract

We aimed to provide a comparative analysis of the vaginal microbiota in pregnant women who underwent cervical conization (CZ) and radical trachelectomy (RT) for cervical intraepithelial neoplasia or early-stage cervical cancer. We included 114 pregnant Japanese women who underwent CZ group (n = 13), RT group (n = 20), or received no cervical treatments (CON group: n = 81) and cared at Keio University Hospital between 2019 and 2023. The differences in vaginal microbiota during the first, second, and third trimester using V1-V2 region of the 16S ribosomal RNA were investigated. Higher species diversity was observed in the CZ and RT groups than in the CON group; however, the abundance and composition of Lactobacillus were similar. The rate of preterm delivery in women who underwent cervical treatments was significantly higher than that in those who had full-term delivery; however, the species diversity and abundance or composition of Lactobacillus was not associated with preterm birth. Women who underwent CZ or RT had higher microbial species diversity than women who did not undergo a procedure; however, Lactobacillus abundance and composition remained the same. The cause of preterm delivery in women who received cervical treatment was not associated with Lactobacillus species diversity or abundance.

Indexed as

ConizationMicrobiotaTrachelectomyUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginaAdultCervix UteriFemaleHumansLactobacillusPregnancyPremature BirthRNA, Ribosomal, 16SRNA, Ribosomal, 16SCervical conizationCommunity state typePreterm deliveryRadical trachelectomyVaginal microbiota

Identifiers

PMID42020714
PMCPMC13273126

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.