ArticleNPJ digital medicine2026
Post-vaccine inflammation tracking: validation of a novel individualized digital inflammatory biomarker relative to serum biomarkers.
Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Inflammatory changes play a central role in both diseases and therapeutic interventions. Wearables are a promising novel method for inflammation detection and tracking through identifying subtle, individualized physiologic changes. We evaluated a wearable-derived individualized digital biomarker, inflammatory multivariate change index (iMCI) against serum biomarkers and reactogenicity following vaccination. Sixty-one volunteers received one of four mRNA vaccines (80 total doses) and wore a torso sensor patch for 14 days starting seven days before vaccination. Changes in serum inflammatory biomarkers symptoms were tracked post-vaccine. iMCI showed moderate to strong correlation against C-reactive protein (CRP; Spearman ρ = 0.59, p < 0.01) and interferon-γ (IFN-γ; ρ = 0.56, p < 0.01), comparable to the CRP-IFN-γ correlation (ρ = 0.60, p < 0.01). Associations with systemic reactogenicity were moderate for all three measures (iMCI ρ = 0.48, p < 0.01; IFN-γ ρ = 0.34, p = 0.01; CRP ρ = 0.36, p < 0.01). These results indicate that a personalized digital biomarker offers a scalable alternative to serial blood testing for real-time inflammation tracking.
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