ReviewPflugers Archiv : European journal of physiology2026
Proximal TGF-β Signaling in Chronic Injury: from a notorious fibrotic factor to a repair ally.
Review in Pflugers Archiv : European journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Transforming growth factor beta (TGF-β) is a pleiotropic factor that plays a key role in the pathophysiology of chronic kidney disease (CKD). However, targeting TGF-β inhibition failed to mitigate CKD in practice. The proximal tubule (PT), the most vulnerable renal segment, plays a central role in post-injury repair or the drift to CKD. Despite its well-documented profibrotic effects, recent studies revealed benefits of TGF-β signaling in PT response to CKD, raising the question of its therapeutic potential. This review highlights mechanisms by which TGF-β signaling mediates the PT adaptive response to chronic injury and provides perspectives for developing novel CKD therapy.
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