Antibacterial properties and hemolysis test of co-doped (Na

Nataliia Strutynska, Yeva Komashchenko, Iryna Grynyuk, Olha Vasyliuk, Dmytro Prokhorenko, Oksana Livitska

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Nataliia StrutynskaTaras Shevchenko National University of Kyiv, 64/13, Volodymyrska Street, Kyiv, 01601, Ukraine.

Yeva KomashchenkoTaras Shevchenko National University of Kyiv, 64/13, Volodymyrska Street, Kyiv, 01601, Ukraine.

Iryna GrynyukIgor Sikorsky Kyiv Polytechnic Institute, 37, Peremohy av., Kyiv, 03056, Ukraine.

Olha VasyliukZabolotny Institute of Microbiology and Virology, National Academy of Science of Ukraine, 154, Akademika Zabolotnoh Street, Kyiv, 03143, Ukraine.

Dmytro ProkhorenkoIgor Sikorsky Kyiv Polytechnic Institute, 37, Peremohy av., Kyiv, 03056, Ukraine.

Oksana LivitskaEnamine Ltd,, 78 Winston Churchill Street, Kyiv, 02094, Ukraine. oksanalivitska@gmail.com.

Funding

This research was supported by National Research Foundation of Ukraine Grant №2023.03/0109)

6 · The paper itself

Abstract

This study presents a one-stage synthesis of multifunctional composites based on co-doped hydroxyapatite (HAP) and zinc/copper ferrites via the evaporation of multicomponent aqueous solutions followed by annealing to 600 °C. X-ray diffraction analysis confirmed the formation of HAP and ferrite phases. The biological evaluation revealed that the synthesized composites possess pronounced membrane-stabilizing properties. In vitro hemolysis assays showed a decrease of the maximum hemolysis level from 57 to 37–49% at adding of composites in concentrations of 1–2 mg/ml, effectively prolonging the hemolysis process by up to 20 s. Furthermore, the composites exhibited noticeable antimicrobial activity against opportunistic pathogens. The composite based on co-doped (0.25 mol% Na+, 0.25 mol% Zn2+, 0.5 mol% CO32−)-HAP with 25 wt% of CuFe2O4 demonstrated the highest efficacy against Gram-positive Staphylococcus aureus, showing up to a 16.4-fold growth inhibition. In contrast, Gram-negative Pseudomonas aeruginosa displayed higher resistance, likely due to its more complex cell wall structure. Obtained results suggest the potential of the developed co-doped (Na+, Cu2+/Zn2+, CO32−) hydroxyapatite/(Cu/Zn)Fe2O4 composites for biomedical application.

Indexed as

Anti-Bacterial AgentsDurapatiteFerric CompoundsHemolysisCopperMicrobial Sensitivity TestsPseudomonas aeruginosaStaphylococcus aureusX-Ray DiffractionZincAnti-Bacterial AgentsCopperDurapatiteFerric CompoundsZincAntimicrobial activityBiotechnologyFerriteHemolysisMembrane-stabilizing effectModified hydroxyapatite

Identifiers

PMID42020519

DOI10.1038/s41598-026-47072-x

PMCPMC13272812

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.