ArticleEMBO reports2026
The reprogramming and function of H4K20me1 during early embryo development.
Xiangrui Meng, Zhen He, Dong Fang, Wenbo Li, Jia Guo, Jiacheng Lu, Fen Yan, Xin Dong, Lingling Chen, Sarmir Khan and 2 more
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In one paragraphArticle in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Xiangrui Meng *The First Affiliated Hospital of Zhengzhou University & Institute of Reproductive Health, Henan Academy of Innovations in Medical Science, Zhengzhou, China.ORCID 0009-0007-8671-9364 Dong Fang *Luoyang Maternal and Child Health Hospital, Luoyang, China.
Wenbo Li *The First Affiliated Hospital of Zhengzhou University & Institute of Reproductive Health, Henan Academy of Innovations in Medical Science, Zhengzhou, China.
Jia GuoThe First Affiliated Hospital of Zhengzhou University & Institute of Reproductive Health, Henan Academy of Innovations in Medical Science, Zhengzhou, China.
Jiacheng LuThe First Affiliated Hospital of Zhengzhou University & Institute of Reproductive Health, Henan Academy of Innovations in Medical Science, Zhengzhou, China.
Fen YanThe First Affiliated Hospital of Zhengzhou University & Institute of Reproductive Health, Henan Academy of Innovations in Medical Science, Zhengzhou, China.
Xin DongThe First Affiliated Hospital of Zhengzhou University & Institute of Reproductive Health, Henan Academy of Innovations in Medical Science, Zhengzhou, China.
Lingling ChenThe First Affiliated Hospital of Zhengzhou University & Institute of Reproductive Health, Henan Academy of Innovations in Medical Science, Zhengzhou, China.ORCID 0009-0002-7898-9384 Sarmir KhanThe First Affiliated Hospital of Zhengzhou University & Institute of Reproductive Health, Henan Academy of Innovations in Medical Science, Zhengzhou, China.
Chunling WangNHC Key Laboratory of Birth Defects Prevention, Zhengzhou, China.
Jiawei XuThe First Affiliated Hospital of Zhengzhou University & Institute of Reproductive Health, Henan Academy of Innovations in Medical Science, Zhengzhou, China. fccxujw@zzu.edu.cn.ORCID 0000-0003-4336-7972 Funding
Henan AIMS Professional Development Fund JBKY250314Henan Province medical science and technology research project of the major project of the province SBGJ202401007Henan Province University science and technology innovation team 24IRTSTHN037Henan Zhongyuan Medical Science and Technology Innovation Development Foundation ZYYC202304ZDJoint fund for the cultivation of superior disciplines 222301420013MOST | National Key Research and Development Program of China (NKPs) 2024YFC3405404MOST | National Natural Science Foundation of China (NSFC) 32170819Scientific Research Innovation team of the First Affiliated Hospital of Zhengzhou University Excellent innovation team ZYCXTD2023004
6 · The paper itselfAbstract
Histone modifications play critical roles in regulating chromatin dynamics and embryonic development. Among these, histone H4 lysine 20 mono-methylation (H4K20me1) is an essential epigenetic mark associated with gene expression and genome stability. However, the reprogramming and functional roles of H4K20me1 in early embryogenesis remain unclear. Here, we map genome-wide distributions of H4K20me1 in mouse, human, and zebrafish early embryos, revealing a broad distribution pattern along with species-specific features. H4K20me1 is predominantly enriched in gene bodies and undergoes dynamic erasure and reestablishment following fertilization. Functional perturbation of SET8, the only known H4K20me1 methyltransferase, results in developmental arrest, highlighting its necessity for embryogenesis. Mechanistically, H4K20me1 is crucial for zygotic genome activation (ZGA), where it regulates RNA synthesis and transcription, and promotes chromatin accessibility. Our findings provide insights into the dynamic reprogramming and regulatory functions of H4K20me1 in early developmental processes.
Indexed as
Cellular ReprogrammingEmbryonic DevelopmentHistonesAnimalsChromatinEpigenesis, GeneticGene Expression Regulation, DevelopmentalHistone-Lysine N-MethyltransferaseHumansMethylationMiceZebrafishZygoteChromatinHistone-Lysine N-MethyltransferaseHistones
Identifiers
PMID42020515
PMCPMC13261155
What OpenQuestion holds
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LicenceCC BY
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