Evidence map›Paper›PMID 42020513›Full record

ReviewNature reviews. Immunology2026

Lymphocyte-mediated immune responses to Leishmania infection.

Christian R Engwerda, Paul M Kaye, Simona Stäger

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christian R EngwerdaImmunology and Infection Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. christian.engwerda@qimrb.edu.au.ORCID http://orcid.org/0000-0003-2813-4804
Paul M KayeHull York Medical School and York Biomedical Research Institute, University of York, York, UK. paul.kaye@york.ac.uk.ORCID http://orcid.org/0000-0002-8796-4755
Simona StägerCentre Armand-Frappier Santé Biotechnologie and Infectiopôle INRS, Laval, Quebec, Canada. simona.stager@inrs.ca.ORCID http://orcid.org/0000-0001-5508-9565

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmania are intracellular protozoan parasites transmitted to humans by the bite of infected phlebotomine sand flies. Human infection is often asymptomatic but can develop into a broad spectrum of clinical diseases, collectively termed the leishmaniases. The underlying immunological features associated with asymptomatic infection and the varying clinical forms of disease have been extensively studied in pre-clinical models (including rodents, dogs and primates), as well as in human populations. Here, concentrating on data derived from human studies, we review the current understanding of how diverse lymphocyte-mediated immune responses drive the human disease spectrum seen following Leishmania infection.

Indexed as

Immunity, CellularLeishmaniaLeishmaniasisLymphocytesAnimalsHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.