ArticleNature communications2026
A rice ceRNA module suppresses Rhizoctonia solani-induced cross-kingdom RNAi to reduce fungal pathogenicity.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Epigenetic Control of Cold Stress Tolerance in Plants: Emerging Mechanisms and Applications for Crop Improvement.International journal of molecular sciences · 2026Review
- (E)-2-Hexenal Combats Rice Sheath Blight Through Direct Pathogen Inhibition and Host Defense Reprogramming.Plants (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cross-kingdom RNA interference (RNAi) is a key virulence mechanism in which pathogens deliver small RNAs (sRNAs) into host plants, hijacking host ARGONAUTE (AGO) proteins to silence immunity-related genes. However, systematic studies on cross-kingdom RNAi in staple crops, such as rice, remain lacking. Moreover, the mechanism by which plants modulate cross-kingdom RNAi to restrict pathogen invasion is unknown. Here, we identify OsAGO proteins potentially hijacked by R. solani and perform comprehensive sRNA sequencing to profile fungal-derived sRNAs targeting rice genes. Our analysis reveals two R. solani-derived sRNAs that specifically bind OsAGO1 to silence two rice defense genes: Cytochrome P450 98A1 (OsCYP98A1) and NIMA-related kinase 6 (OsNEK6). Notably, we find that OsmiR168 fine-tunes cross-kingdom RNAi efficiency by regulating OsAGO1 mRNA levels. More importantly, a long non-coding RNA, LncRNA19164, acts as a competing endogenous RNA (ceRNA) to sequester OsmiR168, thereby stabilizing OsAGO1 transcripts and regulating cross-kingdom RNAi. Our findings not only advance the understanding of cross-kingdom RNAi in plant-pathogen interactions but also provide a foundation for developing RNA-based disease control strategies in crops.
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Registered trials
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