ArticleNature communications2026
High-speed multiplexed DNA-PAINT imaging of nuclear organization using an expanded sequence repertoire.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- O-SNAP uncovers nanoscale chromatin remodeling in dedifferentiation and stress responses.Nature communications · 2026Article
- Accelerated Left-Handed DNA-PAINT Using Fluorogenic Probes.Nano letters · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
DNA-Points Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) enables multiplexed super-resolution imaging of biological samples. We expand the repertoire of speed-optimized DNA-PAINT sequences to visualize up to twelve targets in a sequential manner. By implementing Exchange-PAINT protocol, we demonstrate 12-plex super-resolved imaging of DNA origami nanostructures within four hours with a localization precision of 3-5 nm. Using these sequences, we demonstrate 9-plex super-resolution imaging of diverse nuclear targets. Further, we present a comprehensive analysis pipeline to quantify nanoscale chromatin organization in single cells. Combining multiplexed imaging with this pipeline enabled us to capture loss of chromatin contacts with nuclear speckles upon global transcription inhibition. This work highlights the ability to simultaneously image multiple targets at accelerated speeds while maintaining high spatial resolution, enabling in-depth mapping of the nuclear landscape. These speed-optimized imager sequences for multiplexed super-resolution imaging will drive its further adoption for diverse cellular imaging applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.