Evidence map›Paper›PMID 42020334›Full record

Trial reportVox sanguinis2026

Effects of pre-donation salt-loading on the occurrence of delayed vasovagal reactions.

Noriko Namba, Gaku Kondo, Fumihiko Ishimaru, Tatsuma Hashizume, Yoshie Yamauchi, Noriko Yano, Yoko Ikeda, Keiko Kagawa, Miwa Nakagawa, Noriko Kunii and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Vox sanguinis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Noriko NambaJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.ORCID https://orcid.org/0000-0003-2951-3451
Gaku KondoJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.
Fumihiko IshimaruJapanese Red Cross Blood Service Headquarters, Tokyo, Japan.ORCID https://orcid.org/0000-0002-7668-6083
Tatsuma HashizumeJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.
Yoshie YamauchiJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.
Noriko YanoJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.
Yoko IkedaJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.
Keiko KagawaJapanese Red Cross Blood Service Headquarters, Tokyo, Japan.
Miwa NakagawaJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.
Noriko KuniiJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.
Chiharu KanoJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.
Kiichi AokiJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.
Yoshihiro SawamuraJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.ORCID https://orcid.org/0009-0001-4393-7325
Shigeyoshi MakinoJapanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan.

Funding

Japanese Red Cross Society
6 · The paper itself

Abstract

BACKGROUND AND

objectivesVasovagal reaction (VVR) is the most frequent adverse reaction in blood donation, which usually recovers soon without complications. However, syncopal VVR can result in severe injury due to a fall. Some reports have shown the possibility to prevent VVR with salt-loading prior to blood donation. This semi-randomized controlled study aims to clarify the preventive effect of salt-loading on VVR among whole blood (WB) donors. MATERIALS AND

methodsDuring the study period, donors who donated 400 mL of WB on odd days were assigned to the salt-loading group and those who donated on even days to the control group. Participants in the salt-loading group were asked to take three tablets containing 0.3 g salt in total.

resultsThe incidence of VVRs occurring >20 min after needle removal (delayed VVR [dVVR]) did not significantly differ between the two groups. Secondary analysis suggested a possible dose-dependent preventive effect against dVVR (odds ratio [OR]: 0.70; 95% confidence interval [CI]: 0.52-0.94; p = 0.02). The number of delayed syncopal VVR episodes in summer was lower in the salt-loading group than in the control group (n = 1 vs. 8; OR: 0.13; p = 0.04; pre-specified α = 0.0125).

conclusionThere was no significant preventive effect of pre-donation salt-loading on VVR. Further investigations with sufficient number of participants are needed to conclude the suggested dose dependency and seasonal preventive effect on dVVRs.

Indexed as

Blood DonationBlood DonorsSodium ChlorideSyncope, VasovagalAdultFemaleHumansMaleSodium Chlorideblood donationdelayed VVRpreventive effectsalt‐loadingsyncopal VVRvasovagal reaction

Identifiers

PMID42020334
PMCPMC13356999

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.