Evidence map›Paper›PMID 42019989›Full record

ArticleBMJ (Clinical research ed.)2026

Home environment conditions during childhood and psychosocial outcomes across three generations in Sweden: population based adoption-discordant sibling comparison study.

Zhenxin Liao, Mengping Zhou, Isabell Brikell, Zheng Chang, Ralf Kuja-Halkola, Brian M D'Onofrio, Henrik Larsson, Paul Lichtenstein, Erik Pettersson

Abstract readComparative Study
In one paragraph

Article in BMJ (Clinical research ed.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenxin LiaoDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0009-0008-1373-4050
Mengping ZhouDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Isabell BrikellDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Zheng ChangDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ralf Kuja-HalkolaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Brian M D'OnofrioDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Henrik LarssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Erik PetterssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo examine if early adoption into a family with favourable home environment conditions reduces long term psychosocial risks and provides intergenerational benefits among individuals born to parents with psychiatric or behavioural problems.

designPopulation based adoption-discordant sibling comparison study.

settingSwedish registers of births between 1950 and 1980, with follow-up to 31 December 2020.

participantsTwo samples of sibling pairs from at risk families: 4254 full siblings and 7796 maternal half siblings, who were or were not adopted before age 10 years. Offspring of these siblings (born 1965-2020) were also followed to assess intergenerational spillover effects.

main outcome measuresThe variable of interest was adoption into non-biological families. Outcomes included psychiatric diagnoses, long term unemployment, receipt of social welfare, highest attained education (and upper secondary education ineligibility for generation 3), criminal convictions, and, among men, non-cognitive skills and general intelligence assessed at military conscription.

resultsAdopted individuals (n=1535) showed a lower risk of psychiatric disorders (29.8%

conclusionsEarly adoption into a family with favourable home environment conditions was associated with moderate, enduring benefits across psychiatric, social, and cognitive outcomes, extending into the next generation. These results highlight the potential for environmental improvements during childhood to mitigate intergenerational disadvantage.

Indexed as

AdoptionMental DisordersSiblingsSocial EnvironmentAdultChildFemaleHumansMaleRegistriesSocial WelfareSweden

Identifiers

PMID42019989
PMCPMC13101412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.