Evidence map›Paper›PMID 42019709›Full record

ArticleExperimental hematology2026

SiglecF-expressing neutrophils differentiate from mature neutrophils locally in the heart after myocardial infarction.

Jonah K Stephan, Taylor Knerr, William S Isaacs, Yibing Nong, Marcin Wysoczynski

Abstract read
In one paragraph

Article in Experimental hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonah K StephanCenter for Cardiometabolic Science, Christina Lee Brown Envirome Institute, University of Louisville School of Medicine, Louisville, KY.
Taylor KnerrCenter for Cardiometabolic Science, Christina Lee Brown Envirome Institute, University of Louisville School of Medicine, Louisville, KY.
William S IsaacsCenter for Cardiometabolic Science, Christina Lee Brown Envirome Institute, University of Louisville School of Medicine, Louisville, KY.
Yibing NongCenter for Cardiometabolic Science, Christina Lee Brown Envirome Institute, University of Louisville School of Medicine, Louisville, KY.
Marcin WysoczynskiCenter for Cardiometabolic Science, Christina Lee Brown Envirome Institute, University of Louisville School of Medicine, Louisville, KY. Electronic address: marcin.wysoczynski@louisville.edu.

Funding

TBDP30GM127607 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2018 to 2022
$6.3M
Exercise-enhanced resolution of inflammationR01GM127495 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HELLMANN, JASON L · 2018 to 2022
$2.5M
The role of bioactive lipids in CMC-induced myocardial repair.R01HL141191 · NHLBI · UNIVERSITY OF LOUISVILLE · PI WYSOCZYNSKI, MARCIN · 2019 to 2023
$1.9M
Emergency Granulopoiesis in Ventricular RemodelingR01HL175510 · NHLBI · UNIVERSITY OF LOUISVILLE · PI Marcin Wysoczynski · 2025 to 2026
$1.4M
Imaging and Physiology Core: High Frequency, High Resolution Ultrasound Imaging SystemS10OD025178 · OD · UNIVERSITY OF LOUISVILLE · PI JONES, STEVEN P · 2019 to 2019
$364k
The Role of Emergency Granulopoiesis in Wound Healing after Myocardial InfarctionF31HL174069 · NHLBI · UNIVERSITY OF LOUISVILLE · PI STEPHAN, JONAH · 2024 to 2025
$72k
NHLBI NIH HHS F31 HL174069NHLBI NIH HHS R01 HL141191NHLBI NIH HHS R01 HL175510NIGMS NIH HHS P30 GM127607NIGMS NIH HHS R01 GM127495NIH HHS S10 OD025178
6 · The paper itself

Abstract

Myocardial infarction (MI) triggers an immune response marked by rapid infiltration of neutrophils. Although once considered a uniform population, neutrophils display remarkable heterogeneity post-MI, including a subset expressing SiglecF, a marker typically associated with eosinophils. In this study, we investigated the origin of SiglecF

Indexed as

Cell DifferentiationMyocardial InfarctionMyocardiumNeutrophilsAnimalsGranulocyte-Macrophage Colony-Stimulating FactorMaleMiceMice, Inbred C57BLSialic Acid Binding Immunoglobulin-like LectinsTransforming Growth Factor betaGranulocyte-Macrophage Colony-Stimulating FactorSialic Acid Binding Immunoglobulin-like LectinsSiglecf protein, mouseTransforming Growth Factor beta

Identifiers

PMID42019709
PMCPMC13234759

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.