Evidence map›Paper›PMID 42019669›Full record

ArticleEnvironmental research2026

Association between gestational and childhood exposures to organophosphate esters and social skill, problem behavior among adolescents.

Jagadeesh Puvvula, Joseph M Braun, Kimberly Yolton, Kim M Cecil, Antonia M Calafat, Maria Ospina, Whitney Fitts, Kelli M Williams, Weili Yang, Ann M Vuong and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jagadeesh PuvvulaDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: Jagadeesh.Puvvula@pennmedicine.upenn.edu.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, RI, USA.
Kimberly YoltonDepartment of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Kim M CecilDepartment of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Antonia M CalafatNational Center for Environmental Health, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Maria OspinaNational Center for Environmental Health, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Whitney FittsDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kelli M WilliamsDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Weili YangDepartment of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ann M VuongDepartment of Epidemiology and Biostatistics, School of Public Health, University of Nevada Las Vegas, Las Vegas, NV, USA.
Zana PercyDepartment of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Bruce LanphearFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Child and Family Research Institute, BC Children's Hospital, Vancouver, BC, Canada.
Aimin ChenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIAU01AG088658 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Aimin Chen, Lifang Hou · 2024 to 2026
$6.5M
Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4M
Philadelphia Regional Center for Children’s Environmental HealthP2CES033428 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Aimin Chen, Marilyn Howarth · 2022 to 2026
$5.4M
Developmental neurotoxicity of organophosphate and novel brominated flame retardants in childrenR01ES028277 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, AIMIN · 2017 to 2022
$3.4M
Early life perfluoroalkyl substance exposure & obesity: Mechanisms & phenotypingR01ES025214 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2016 to 2020
$3.1M
Internalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC ExposuresR01ES027224 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, YOLTON, KIMBERLY · 2016 to 2020
$3.0M
A Community-Based Trial to Prevent Lead Poisoning and InjuriesR01ES014575 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI YOLTON, KIMBERLY · 2007 to 2011
$2.9M
Longitudinal study of exposure to PBDEs and PFCs and child neurobehaviorR01ES020349 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN, LANPHEAR, BRUCE P · 2011 to 2015
$2.9M
Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic HealthR01ES032836 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2021 to 2024
$2.4M
Early life organophosphate ester (OPE) exposures and adiposity and cardiometabolic health during adolescenceR01ES033200 · NIEHS · UNIVERSITY OF NEVADA LAS VEGAS · PI Ann Vuong · 2022 to 2026
$2.0M
NIA NIH HHS U01 AG088658NIEHS NIH HHS P01 ES011261NIEHS NIH HHS P2C ES033428NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES014575NIEHS NIH HHS R01 ES020349NIEHS NIH HHS R01 ES025214NIEHS NIH HHS R01 ES027224NIEHS NIH HHS R01 ES028277NIEHS NIH HHS R01 ES032836NIEHS NIH HHS R01 ES033200
6 · The paper itself

Abstract

Early life exposure to organophosphate esters (OPEs), a class of flame retardants and plasticizers, may be associated with adverse neurobehavioral outcomes. Due to OPEs' relatively short biological half-life in humans, it is important to evaluate exposure-response associations using repeated measures during gestation and childhood. We examined the associations between OPE biomarkers and social skill/problem behavior using data from 236 caregiver-adolescent dyads in the Health Outcomes and Measures of the Environment (HOME) Study. We included urinary concentrations of four OPE biomarkers [bis-2-chloroethyl-phosphate (BCEP), bis(1,3-dichloro-2-propyl)-phosphate (BDCIPP), di-n-butyl-phosphate (DNBP), diphenyl-phosphate (DPHP)] measured up to 9 times (3 in gestation and 6 in childhood) and calculated cumulative exposure measures during gestation, childhood, and the lifetime. Social and behavioral outcomes at age 12 years were assessed using the Social Skills Improvement System (SSiS) completed by adolescents and caregivers. We used quantile g-computation regression to evaluate joint associations between the OPE biomarker mixture and SSiS scores, while adjusting for covariates. Overall, we observed null associations between OPE biomarkers and adolescent social skill/problem behavior scores, but the effect measure modification by adolescent sex was statistically significant. Every quartile increase in childhood/lifetime OPE biomarker mixture was associated with improved caregiver-reported problem behavior among females (Ψ

Indexed as

Environmental ExposureFlame RetardantsOrganophosphatesPrenatal Exposure Delayed EffectsProblem BehaviorSocial SkillsAdolescentBiomarkersChildEstersFemaleHumansMalePregnancyBiomarkersEstersFlame RetardantsOrganophosphatesAnd repeated exposuresBehaviorOrganophosphate estersSocial skills

Identifiers

PMID42019669
PMCPMC13267135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.