Evidence map›Paper›PMID 42019204›Full record

ArticleInternational dental journal2026

Significance of Methyltransferase-like 5 Expression in Oral Squamous Cell Carcinoma.

Yuka Kajiya, Kaori Shima, Yudai Shimojukkoku, Yasunobu Oku, Takahiro Tsuchiyama, Kanako Higashimoto, Miyako Kurihara-Shimomura, Tomonori Sasahira

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Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yuka KajiyaDepartment of Molecular Oral Pathology and Oncology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Kaori ShimaDepartment of Molecular Oral Pathology and Oncology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Yudai ShimojukkokuDepartment of Molecular Oral Pathology and Oncology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan; Department of Oral Surgery, Saitama Cancer Center, Ina-machi, Japan.
Yasunobu OkuDepartment of Molecular Oral Pathology and Oncology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Takahiro TsuchiyamaDepartment of Molecular Oral Pathology and Oncology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan; Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Kanako HigashimotoDepartment of Molecular Oral Pathology and Oncology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan; Department of Oral Surgery, Field of Oral and Maxillofacial Rehabilitation, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Miyako Kurihara-ShimomuraDepartment of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan.
Tomonori SasahiraDepartment of Molecular Oral Pathology and Oncology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. Electronic address: sasa33@dent.kagoshima-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesOral squamous cell carcinoma (OSCC) is a malignant tumour with high-local invasiveness and lymph node metastasis potential. It is associated with poor prognosis and postoperative cosmetic complications. Therefore, developing molecular targets for early detection, diagnosis, and treatment is imperative. Methyltransferase-like 5 (METTL5), a newly identified N6-methyladenosine (m6A) modification writer, has been shown to exhibit tumour-promoting functions in several cancers. However, the significance of METTL5 expression in OSCC remains unexplored.

methodsIn this study, we performed gene expression and in silico analyses of METTL5 and related molecules using publicly available datasets. The clinicopathological significance of METTL5 was assessed by immunohistochemistry (IHC) in 62 OSCC specimens.

resultsAnalysis of public databases revealed that METTL5 expression was highly elevated in head and neck SCC. Genes related to METTL5, including TP53RK-binding protein (TPRKB) and ZZ-type zinc finger and EF-hand domain protein 1 (ZZEF1), were identified. Furthermore, METTL5 expression levels were positively correlated with those of ferroptosis-related genes. IHC analysis revealed that METTL5 expression was associated with local tumour progression (P = .0367). Multivariate analysis revealed that METTL5 expression is associated with poor prognosis for overall survival (P = .0376).

conclusionsOur results suggest that METTL5 may serve as a new diagnostic and therapeutic target for OSCC.

Indexed as

Carcinoma, Squamous CellMethyltransferasesMouth NeoplasmsAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMiddle AgedPrognosisRNA MethylationBiomarkers, TumorMethyltransferasesFerroptosisMETTL5Oral cancerTPRKBZZEF1

Identifiers

PMID42019204
PMCPMC13121416

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.