SynthesisActa cirurgica brasileira2026
The use of xenografts with fish skin for the treatment of burns: a systematic review and meta-analysis.
Synthesis in Acta cirurgica brasileira, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
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Abstract
purposeTo conduct a systematic literature review and meta-analysis to assess the efficacy of fish skin xenografts in burn treatment, comparing reepithelialization time, pain reduction, and the amount of analgesics used.
methodsThis review was designed and conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and registered in PROSPERO under registration number CRD42023412250. The databases MEDLINE (via PubMed), Cochrane Library, Scientific Electronic Library Online (SciELO)/Latin American and Caribbean Health Sciences Literature (LILACS), and EMBASE were used. The literature search identified 768 articles. Through title and abstract screening, 736 were excluded, along with 16 duplicates. Sixteen articles were fully analyzed, of which six met the inclusion criteria for this review.
resultsThe systematic review found that patients treated with fish skin xenografts had shorter reepithelialization times and reduced pain compared to conventional treatments. The meta-analysis showed reduction in reepithelialization time for the intervention groups using fish skin grafts by 1.26 day (95% confidence interval [95%CI] -2.38 to -0.15; p < 0.00001) and a reduction in pain levels with score decreases of 3.84 (95%CI -6.42 to -1.26; p = 0.0009). The objective of assessing the number of analgesics used could not be evaluated quantitatively.
conclusionThe use of fish skin xenografts in burn patients is effective in reducing reepithelialization time and decreasing pain levels during treatment.
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