Evidence map›Paper›PMID 42018620›Full record

ArticleScience advances2026

Ancient regulatory evolution shapes individual language abilities in present-day humans.

Lucas G Casten, Tanner Koomar, Taylor R Thomas, Jin-Young Koh, Dabney Hofammann, Savantha Thenuwara, Allison Momany, Marlea O'Brien, Jeffrey C Murray, J Bruce Tomblin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Lucas G CastenDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-7690-6405
Tanner KoomarDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0003-0777-8678
Taylor R ThomasCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-7503-9976
Jin-Young KohDepartment of Otorhinolaryngology Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0002-6785-0515
Dabney HofammannDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
Savantha ThenuwaraCarver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0009-0002-8600-0687
Allison MomanyStead Family Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-5466-7973
Marlea O'BrienDepartment of Communication Science and Disorders, University of Iowa, Iowa City, IA 52242, USA.ORCID 0009-0003-4834-5710
Jeffrey C MurrayStead Family Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.
J Bruce TomblinDepartment of Communication Science and Disorders, University of Iowa, Iowa City, IA 52242, USA.
Jacob J MichaelsonDepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-9713-0992

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Language is a defining feature of our species, yet the genomic changes enabling it remain poorly understood. Despite decades of work since

Indexed as

Biological EvolutionEvolution, MolecularLanguageAnimalsForkhead Transcription FactorsHumansNeanderthalsSelection, GeneticForkhead Transcription Factors

Identifiers

PMID42018620
PMCPMC13101878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.