Evidence map›Paper›PMID 42018614›Full record

ArticleScience advances2026

Estimating in silico causal effects of DNA methylation on gene expression through genetic anchors in airway epithelium in asthma.

Soyeon Kim, Rebecca I Caldino Bohn, Aditya Sriram, Hyun Jung Park, Ziyu Huang, Wei Chen, Juan C Celedón

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Soyeon KimDivision of Pulmonary Medicine, Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-1573-2733
Rebecca I Caldino BohnDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0009-0009-5584-8483
Aditya SriramDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-7303-9529
Hyun Jung ParkDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-8324-2624
Ziyu HuangBiostatistics Facility, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.ORCID 0000-0002-9062-1614
Wei ChenDivision of Pulmonary Medicine, Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-7196-8703
Juan C CeledónDivision of Pulmonary Medicine, Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-6139-5320

Funding

Identifying Genetic and Epigenetic Risk Factors Regulating Gene Expression for Childhood AsthmaK01HL153792 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KIM, SOYEON · 2020 to 2025
$699k
NHLBI NIH HHS K01 HL153792
6 · The paper itself

Abstract

Expression quantitative trait methylation (eQTM) analyses have identified numerous associations between DNA methylation (DNAm) and gene expression, but the causal pathways underlying such associations remain poorly understood. Using single-nucleotide polymorphisms (SNPs) as genetic anchors, we examined potential causal effects between DNAm and gene expression in cis and trans associations in nasal epithelial samples from youth with (

Indexed as

AsthmaDNA MethylationGene Expression RegulationAdolescentChildComputer SimulationEpigenesis, GeneticFemaleGenetic Predisposition to DiseaseHumansMalePolymorphism, Single NucleotideQuantitative Trait Loci

Identifiers

PMID42018614
PMCPMC13101850

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.