Evidence map›Paper›PMID 42018613›Full record

ArticleScience advances2026

Patterns of mitochondrial ATP predict tissue folding.

Bezia Lemma, Megan Rothstein, Pengfei Zhang, Bridget Waas, Marcus Kilwein, Safiya Topiwala, Sherry X Zhang, Anvitha Sudhakar, Katharine Goodwin, Elizabeth R Gavis and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Bezia LemmaDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0003-3542-069X
Megan RothsteinDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-5165-9505
Pengfei ZhangDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-8578-8305
Bridget WaasDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0003-1581-5985
Marcus KilweinDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-1185-7881
Safiya TopiwalaDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0009-0003-8062-4373
Sherry X ZhangDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.ORCID 0009-0009-3190-2158
Anvitha SudhakarMechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.
Katharine GoodwinLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-4823-7491
Elizabeth R GavisDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0003-0251-0760
Ricardo MallarinoDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-8971-4864
Andrej KosmrljMechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0001-6137-9200
Celeste M NelsonDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0001-9973-8870

Funding

Mechanical Clocks During Fetal DevelopmentDP1HD111539 · NICHD · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2022 to 2025
$5.7M
Interplay between mechanical forces and retinoic acid in lung developmentR01HL164861 · NHLBI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2022 to 2025
$2.2M
Mechanical Forces and the Regulation of Airway Progenitor CellsR01HD099030 · NICHD · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2019 to 2023
$1.7M
Uncovering the mesenchyme-specific roles of planar cell polarity in lung developmentR01HL166311 · NHLBI · PRINCETON UNIVERSITY · PI Danelle N Devenport, Celeste M Nelson · 2025 to 2026
$1.2M
NHLBI NIH HHS R01 HL164861NHLBI NIH HHS R01 HL166311NICHD NIH HHS DP1 HD111539NICHD NIH HHS R01 HD099030
6 · The paper itself

Abstract

The construction of tissue shapes during embryonic development results from patterns of gene expression and mechanical forces fueled by chemical energy from ATP hydrolysis. We find that chemical energy is similarly patterned during apical constriction, which is widely used across the animal kingdom to fold epithelial tissues. Time-lapse imaging, spatial transcriptomics, and measurements of oxygen consumption rate reveal that mitochondrial density, potential, and ATP increase at the apical side of epithelial cells before actomyosin contraction and tissue folding, which is prevented by inhibiting oxidative phosphorylation. Mitochondrial enrichment and apical bias are conserved during apical constriction in flies, chicks, and mice, and these patterns can be used to predict computationally patterns of tissue folding. These findings highlight a spatial dimension of bioenergetics in development.

Indexed as

Adenosine TriphosphateMitochondriaAnimalsChickensEnergy MetabolismEpithelial CellsMiceOxidative PhosphorylationOxygen ConsumptionAdenosine Triphosphate

Identifiers

PMID42018613
PMCPMC13101848

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.