Evidence map›Paper›PMID 42018612›Full record

ArticleScience advances2026

Selective elimination of circulating effector CD8 T cells via LTβR blockade separates anti-CD137 efficacy from toxicity.

Sergey A Shein, Anna A Korchagina, Li-Ju Wang, Zhao Lai, Yidong Chen, Jacob S Fisher, Burkhard Ludewig, Jessica N Lancaster, Yang-Xin Fu, Ekaterina Koroleva and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sergey A SheinDepartment of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0003-0258-425X
Anna A KorchaginaDepartment of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0001-6177-2379
Li-Ju WangDepartment of Molecular Medicine, UTHSCSA, San Antonio, TX, USA.ORCID 0009-0005-5385-459X
Zhao LaiDepartment of Molecular Medicine, UTHSCSA, San Antonio, TX, USA.
Yidong ChenGreehey Children's Cancer Research Institute, San Antonio, TX, USA.ORCID 0000-0001-6806-2185
Jacob S FisherDepartment of Immunology, Mayo Clinic, Phoenix, AZ, USA.ORCID 0009-0006-6805-3725
Burkhard LudewigInstitute of Immunobiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.ORCID 0000-0002-7685-573X
Jessica N LancasterDepartment of Immunology, Mayo Clinic, Phoenix, AZ, USA.ORCID 0000-0003-0398-9988
Yang-Xin FuSchool of Basic Medical Sciences, Tsinghua University, Beijing, China.ORCID 0000-0001-8441-6617
Ekaterina KorolevaDepartment of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0003-1857-9199
Alexei V TumanovDepartment of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0001-6042-0152

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Lymphotoxin-Beta Receptor Peripheral Signaling Regulates the Transition to Inflammation and Neuropathy-Induced Chronic PainR01NS112263 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AKOPIAN, ARMEN N, TUMANOV, ALEXEI V · 2020 to 2024
$2.4M
The role of lymph node structural organization in naïve T cell decline with ageR01AG080037 · NIA · MAYO CLINIC ARIZONA · PI Jessica N Lancaster · 2023 to 2026
$2.4M
Advancing Cancer Research Through Next Generation Sequencing at Mays Cancer Center of UT Health San AntonioR50CA265339 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Zhao Lai · 2022 to 2026
$957k
High Throughput DNA Sequencer: Illumina HiSeq 3000 SequencerS10OD021805 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2016 to 2016
$600k
FACSAria Fusion cell sorter for Flow Cytometry Shared ResourceS10OD030432 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BERTON, MICHAEL T · 2022 to 2022
$596k
NCI NIH HHS P30 CA054174NCI NIH HHS R50 CA265339NIA NIH HHS R01 AG080037NIH HHS S10 OD021805NIH HHS S10 OD030432NINDS NIH HHS R01 NS112263
6 · The paper itself

Abstract

The major barrier to clinical translation of αCD137 immunotherapy is separating antitumor efficacy from hepatotoxicity driven by IFN-γ-producing CD8 T cells. We propose a strategy to limit toxicity by promoting contraction of excessively expanded CD8 T cells. We identify CD11c

Indexed as

CD8-Positive T-LymphocytesImmunotherapyAnimalsFemaleInterferon-gammaLymphotoxin beta ReceptorMaleMiceMice, Inbred C57BLSignal TransductionTumor Necrosis Factor Receptor Superfamily, Member 9Interferon-gammaLymphotoxin beta ReceptorTumor Necrosis Factor Receptor Superfamily, Member 9

Identifiers

PMID42018612
PMCPMC13101849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.