Evidence map›Paper›PMID 42018524›Full record

ArticleJournal of chemical information and modeling2026

Hydrogen-Bonding Changes Cause Differences in Imipenem Breakdown Activity in OXA-48 Variants.

Daojiong Wang, Adrian J Mulholland, James Spencer, Marc W van der Kamp

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daojiong WangSchool of Biochemistry and Cellular and Molecular Medicine, University of Bristol, BristolBS8 1TD, England.ORCID 0000-0001-5097-4047
Adrian J MulhollandCentre for Computational Chemistry, School of Chemistry, University of Bristol, BristolBS8 1TS, England.ORCID 0000-0003-1015-4567
James SpencerSchool of Biochemistry and Cellular and Molecular Medicine, University of Bristol, BristolBS8 1TD, England.ORCID 0000-0002-4602-0571
Marc W van der KampSchool of Biochemistry and Cellular and Molecular Medicine, University of Bristol, BristolBS8 1TD, England.ORCID 0000-0002-8060-3359

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The β-lactamase OXA-48 efficiently hydrolyzes carbapenem antibiotics, especially imipenem. Carbapenem resistance is a rising clinical concern and is frequently associated with OXA-48 and its variants. OXA-48 variants carrying different mutations in the β

Indexed as

beta-LactamasesImipenemEscherichia coli ProteinsHydrogen BondingHydrolysisMolecular Dynamics SimulationMutationbeta-lactamase OXA-48, E colibeta-LactamasesEscherichia coli ProteinsImipenem

Identifiers

PMID42018524
PMCPMC13169374

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.