Evidence map›Paper›PMID 42018441›Full record

ArticleCell reports2026

TgSEC14-LTP1 is a vacuole-secreted SEC14/CRAL-TRIO-like protein required for host DAG flux and PC homeostasis in T. gondii.

Rosalba Cruz-Miron, Christopher Swale, Qinli Liang, Yoshiki Yamaryo-Botté, Christophe-Sébastien Arnold, Mohamed-Ali Hakimi, Cyrille Y Botté, Alexandre Bougdour, Jeroen P J Saeij

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rosalba Cruz-MironDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
Christopher SwaleTeam Host-Pathogen Interactions and Immunity to Infection, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, Grenoble, France.
Qinli LiangDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
Yoshiki Yamaryo-BottéApicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209, Grenoble, France.
Christophe-Sébastien ArnoldApicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209, Grenoble, France.
Mohamed-Ali HakimiTeam Host-Pathogen Interactions and Immunity to Infection, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, Grenoble, France.
Cyrille Y BottéApicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, Université Grenoble Alpes, INSERM U1209, Grenoble, France. Electronic address: cyrille.botte@univ-grenoble-alpes.fr.
Alexandre BougdourTeam Host-Pathogen Interactions and Immunity to Infection, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Grenoble Alpes University, Grenoble, France. Electronic address: alexandre.bougdour@univ-grenoble-alpes.fr.
Jeroen P J SaeijDepartment of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA. Electronic address: jsaeij@ucdavis.edu.

Funding

Restriction of Toxoplasma growth in human cellsR01AI173803 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JEROEN SAEIJ · 2024 to 2026
$1.8M
NIAID NIH HHS R01 AI173803
6 · The paper itself

Abstract

Intracellular apicomplexan parasites depend on host-derived lipids to expand the parasitophorous vacuole (PV) and replicate. Toxoplasma gondii secretes numerous dense granule proteins (GRAs) for PV remodeling, but PV lumen factors that selectively bind host lipids and shape host-to-parasite lipid flux remain poorly defined. Here, we identify TgSEC14-LTP1, a previously uncharacterized GRA with a divergent SEC14/CRAL-TRIO domain. Structural and genetic analyses show that TgSEC14-LTP1 is secreted into the PV lumen and is essential for parasite replication. Lipidomic profiling, protein-lipid pulldown assays,

Indexed as

DiglyceridesPhosphatidylcholinesProtozoan ProteinsToxoplasmaVacuolesAnimalsHomeostasisHost-Parasite InteractionsDiglyceridesPhosphatidylcholinesProtozoan ProteinsCP: MicrobiologyDAG fluxhost-to-parasite PCnon-vesicular trafficPV-lumenTgSEC14-LTP1toxoplasma gondii

Identifiers

PMID42018441
PMCPMC13557300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.