Evidence map›Paper›PMID 42018416›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Novel Knotted Solenoid fold with order-shifted coil arrangement leads to nontrivial 3

Maciej Sikora, Mariusz Mozajew, Julia A Sikorska, Fernando Bruno da Silva, Agata P Perlinska, Anna Kluza, Szymon Niewieczerzal, Maciej Lukaszewicz, Beata Wielgus-Kutrowska, Karolina Stachurska-Korzeniowska and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Novel Knotted Solenoid fold with order-shifted coil arrangement leads to nontrivial 3Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maciej SikoraCentre of New Technologies, University of Warsaw, Warsaw 02-097, Poland.ORCID 0009-0003-0289-276X
Mariusz MozajewCentre of New Technologies, University of Warsaw, Warsaw 02-097, Poland.ORCID 0000-0001-6157-2860
Julia A SikorskaCentre of New Technologies, University of Warsaw, Warsaw 02-097, Poland.ORCID 0000-0002-4117-9225
Fernando Bruno da SilvaCentre of New Technologies, University of Warsaw, Warsaw 02-097, Poland.ORCID 0000-0002-0285-8700
Agata P PerlinskaCentre of New Technologies, University of Warsaw, Warsaw 02-097, Poland.
Anna KluzaCentre of New Technologies, University of Warsaw, Warsaw 02-097, Poland.
Szymon NiewieczerzalCentre of New Technologies, University of Warsaw, Warsaw 02-097, Poland.ORCID 0000-0002-7563-7212
Maciej LukaszewiczDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Warsaw 02-093, Poland.
Beata Wielgus-KutrowskaDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Warsaw 02-093, Poland.ORCID 0000-0002-5049-864X
Karolina Stachurska-KorzeniowskaDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Warsaw 02-093, Poland.
Sophie E JacksonYusuf Hamied Department of Chemistry, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0002-7470-9800
Joanna I SulkowskaCentre of New Technologies, University of Warsaw, Warsaw 02-097, Poland.ORCID 0000-0003-2452-0724

Funding

Narodowe Centrum Nauki (NCN) #2021/43/I/NZ1/03341
6 · The paper itself

Abstract

Herein, we present crystal structures of proteins adopting a fold not identified among known [Formula: see text]-solenoids in current structural databases, a Knotted Solenoid. These proteins exhibit a characteristic solenoidal architecture, closely resembling [Formula: see text]-solenoid proteins. However, a unique "skip-and-backtrack" shift is observed: One coil skips a rotation while the next realigns, distinguishing this fold from previously described solenoids and allowing the formation of a 3

Indexed as

Protein FoldingProteinsAmino Acid SequenceCrystallography, X-RayModels, MolecularProtein ConformationProtein Structure, SecondaryProteinsevolutionKnotted Solenoid foldnontrivial topologyprotein designstructural biology

Identifiers

PMID42018416
PMCPMC13123833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.