Evidence map›Paper›PMID 42018410›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Targeting CRTC2 reverses

Dimitri Robay, Ole Ackermann, Laurent Laborde, Xingyi Shi, Federico Oreglia, Ramona Stump, Sabina Ciaghi, Giorgio G Galli, Laura Holzer, Lorraine Villemin and 11 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Targeting CRTC2 reversesProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Dimitri RobayNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.ORCID 0009-0001-4088-044X
Ole AckermannNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.
Laurent LabordeNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.
Xingyi ShiNovartis Biomedical Research, Oncology, Cambridge, MA 02139.
Federico OregliaNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.
Ramona StumpNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.
Sabina CiaghiNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.ORCID 0009-0003-7146-2114
Giorgio G GalliNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.ORCID 0000-0002-9401-060X
Laura HolzerNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.
Lorraine VilleminNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.
Joel WagnerNovartis Biomedical Research, Oncology, Cambridge, MA 02139.ORCID 0000-0001-6579-2908
Jincheng WuNovartis Biomedical Research, Oncology, Cambridge, MA 02139.ORCID 0000-0002-9776-479X
Lang Ho LeeNovartis Biomedical Research, Oncology, Cambridge, MA 02139.ORCID 0000-0002-9684-160X
Claudia BossenNovartis Pharma, Basel 4056, Switzerland.ORCID 0000-0002-1695-4744
Thanos P MourikisNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.
Millicent GabrielNovartis Biomedical Research, Oncology, Cambridge, MA 02139.ORCID 0009-0005-2185-0519
David RuddyNovartis Biomedical Research, Oncology, Cambridge, MA 02139.ORCID 0000-0001-8244-5609
Haiyan YuNovartis Biomedical Research, Oncology, Cambridge, MA 02139.
Cory JohannessenNovartis Biomedical Research, Oncology, Cambridge, MA 02139.ORCID 0000-0002-2618-1036
Stephane FerrettiNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.ORCID 0009-0001-1990-8946
Carlotta CostaNovartis Biomedical Research, Oncology, Basel 4056, Switzerland.ORCID 0000-0002-1199-2485

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) patients with tumors harboring

Indexed as

Carcinoma, Non-Small-Cell LungDrug Resistance, NeoplasmLung NeoplasmsProtein Serine-Threonine KinasesTranscription FactorsAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesAnimalsCell Line, TumorCyclic AMP Response Element-Binding ProteinHumansImmune Checkpoint InhibitorsImmunotherapyMiceMice, KnockoutMutationAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesCRTC2 protein, humanCrtc2 protein, mouseCyclic AMP Response Element-Binding ProteinImmune Checkpoint InhibitorsProtein Serine-Threonine KinasesSTK11 protein, humanStk11 protein, mouseTranscription FactorsCRTC2ICB resistanceLKB1lung cancerSTK11

Identifiers

PMID42018410
PMCPMC13123801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.