Evidence map›Paper›PMID 42018403›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Beyond gene duplication: A-to-I RNA editing-mediated stop codon readthrough modulates Dbf2 dosage to resolve pleiotropic conflicts.

Yanfei Du, Yu Zhang, Chenhui Wang, Yi Huang, Mengchun Wu, Junqi Huang, Mengde Hou, Qinhu Wang, Cong Jiang, Huiquan Liu

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. A-to-I RNA editing-mediated stop codon read-through inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Reply to Li & Zhang: Adaptive evolution of stop-loss RNA editing inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yanfei Du *State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.ORCID 0009-0008-7473-5129
Yu Zhang *State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.
Chenhui Wang *State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.
Yi HuangState Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.ORCID 0000-0002-6444-2073
Mengchun WuState Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.ORCID 0009-0004-0455-1253
Junqi HuangState Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.ORCID 0009-0006-2766-1783
Mengde HouState Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.
Qinhu WangState Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.ORCID 0000-0003-1251-073X
Cong JiangState Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.ORCID 0000-0002-5634-3200
Huiquan LiuState Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.ORCID 0000-0002-4723-845X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stop codon readthrough is widespread across eukaryotes and often dismissed as translational noise, yet its tissue/stage-specific occurrence suggests adaptive roles in proteome tuning. We asked whether readthrough-related mechanisms can mitigate stage-specific pleiotropic trade-offs without genomic change. In the filamentous ascomycete

Indexed as

Codon, TerminatorFungal ProteinsGene DuplicationGenetic PleiotropyProtein Serine-Threonine KinasesRNA EditingGene DosageGene Expression Regulation, FungalMeiosisSpores, FungalCodon, TerminatorFungal ProteinsProtein Serine-Threonine Kinasesantagonistic pleiotropyA-to-I RNA editingC-terminal extensionstop codon readthroughstop-loss editing

Identifiers

PMID42018403
PMCPMC13123824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.