ArticleeLife2026
HEB collaborates with TCR signaling to upregulate
Johanna S Selvaratnam, Juliana D B da Rocha, Vinothkumar Rajan, Helen Wang, Emily C Reddy, Miki S Gams, Jenny Jiahuan Liu, Cornelis Murre, David Wiest, Cynthia J Guidos and 2 more
Abstract read
In one paragraphArticle in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
Johanna S SelvaratnamBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Juliana D B da RochaBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Vinothkumar RajanBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Helen WangBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Emily C ReddyHospital for Sick Children, Toronto, Canada.
Miki S GamsDepartment of Immunology, University of Toronto, Toronto, Canada.
Jenny Jiahuan LiuBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Cornelis MurreDepartment of Molecular Biology, University of California, San Diego, San Diego, United States.
David WiestBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, United States.
Cynthia J GuidosDepartment of Immunology, University of Toronto, Toronto, Canada.
Funding
The role of TCR, ligand, and signal strength in human γδ T cell developmentP01AI102853 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI DAVID L. WIEST · 2014 to 2026
$26.3MCIHR FDN154332CIHR PJT153058CIHR PJT165973CIHR PJT192050CIHR PPE196061NIAID NIH HHS P01 AI102853NIH HHS 1P01AI102853-06
6 · The paper itselfAbstract
T cells expressing the γδ T cell receptor (TCR) develop in a stepwise process initiating at the αβ/γδ T cell branch point, followed by maturation and acquisition of effector functions, including the ability to produce interleukin-17 (IL-17) as γδT17 cells. Previous studies linked TCR signal strength and fate choices to the transcriptional regulator HEB (
Indexed as
Basic Helix-Loop-Helix ProteinsInhibitor of Differentiation ProteinsReceptors, Antigen, T-Cell, gamma-deltaSignal TransductionTh17 CellsThymus GlandAnimalsCell DifferentiationMiceMice, KnockoutUp-RegulationBasic Helix-Loop-Helix ProteinsIdb3 protein, mouseInhibitor of Differentiation ProteinsReceptors, Antigen, T-Cell, gamma-deltaTcf12 protein, mousedevelopmental biologygamma delta T cellsgene networksimmunologyinflammationmousesingle-cell RNA sequencing
Identifiers
PMID42018340
PMCPMC13102393
What OpenQuestion holds
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LicenceCC BY
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