ReviewEssays in biochemistry2025
The Ubiquitin Script: writing protein fates in chains.
Review in Essays in biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- A special issue of Essays in Biochemistry on proteasome and protein degradation.Essays in biochemistry · 2026Article
- ANP32A interacts with LDHA to modulate glycolysis and ferroptosis in hepatocellular carcinoma.Frontiers in oncology · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ubiquitination is a fundamental post-translational modification that orchestrates a wide range of cellular processes. This modification is executed through a cascade of enzymatic steps involving E1 activating enzymes, E2 conjugating enzymes, and E3 ligases. Among these, E2 enzymes and specific E3 ligases primarily dictate the type of ubiquitin linkage formed. Ubiquitination system can form chains of ubiquitin on any of its seven lysine residues or its N-terminal methionine, each generating a distinct three-dimensional topology. These structurally diverse polyubiquitin chains are selectively recognized by ubiquitin receptors, influencing substrate stability, localization, and interactions. These topologically diverse polyubiquitin chains function as discrete molecular signals, each with distinct physiological outcomes. This review focuses on key developments in our understanding of how specific ubiquitin linkage types participate in various cellular pathways and their implications on the fate and function of the protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.