ReviewJournal of bone and mineral metabolism2026
Stem-cell regulation in periodontium formation and regeneration.
Review in Journal of bone and mineral metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
introductionThe periodontium is a dynamic composite tissue that anchors teeth to the alveolar bone and adapts continuously to mechanical loading and inflammatory challenges throughout life. Its development, homeostasis, and regeneration depend on diverse mesenchymal stem and progenitor cell populations derived from the dental follicle, apical papilla, and periodontal ligament.
resultsRecent advances in in vivo lineage-tracing studies have demonstrated that these progenitors are heterogeneous, and lineage restricted, rather than constituting a uniform stem cell pool. Distinct populations, including PTHrP⁺ dental follicle-derived progenitors and CXCL12⁺ apical papilla cells, contribute differentially to cementum, periodontal ligament, and alveolar bone formation during tooth root development and postnatal remodeling. The fate decisions of these progenitors are tightly regulated by coordinated signaling pathways, including Hedgehog-Foxf, Wnt/β-catenin, and BMP/TGF-β signaling, as well as by mechanotransducive cues. Spatially and temporally precise regulation of these pathways is essential for proper cementogenesis and alveolar bone formation, whereas their dysregulation leads to impaired periodontal regeneration and bone loss. This review summarizes current knowledge of periodontal stem cell biology with a particular emphasis on developmental origins and in vivo regulatory mechanisms and discusses emerging concepts that support endogenous stem cell-based approaches for periodontal regeneration and future therapeutic strategies.
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