Evidence map›Paper›PMID 42018151›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Charles Bonnet syndrome in patients referred for cataract surgery.

Mads Assenholt Nielsen, Jakob Bjerager, Gülsenay Citirak, Yousif Subhi, Lars Morten Holm, Amardeep Singh

Abstract read
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Mads Assenholt NielsenDepartment of Ophthalmology, Rigshospitalet, Valdemar Hansens Vej 3, Glostrup, DK- 2600, Denmark. mads.assenholt.nielsen@regionh.dk.ORCID http://orcid.org/0009-0009-0979-1316
Jakob BjeragerDepartment of Ophthalmology, Rigshospitalet, Valdemar Hansens Vej 3, Glostrup, DK- 2600, Denmark.ORCID http://orcid.org/0000-0002-6620-6242
Gülsenay CitirakDepartment of Ophthalmology, Rigshospitalet, Valdemar Hansens Vej 3, Glostrup, DK- 2600, Denmark.
Yousif SubhiDepartment of Ophthalmology, Rigshospitalet, Valdemar Hansens Vej 3, Glostrup, DK- 2600, Denmark.ORCID http://orcid.org/0000-0001-6620-5365
Lars Morten HolmDepartment of Ophthalmology, Rigshospitalet, Valdemar Hansens Vej 3, Glostrup, DK- 2600, Denmark.ORCID http://orcid.org/0000-0002-1782-7456
Amardeep SinghDepartment of Ophthalmology, Rigshospitalet, Valdemar Hansens Vej 3, Glostrup, DK- 2600, Denmark.ORCID http://orcid.org/0000-0003-1955-4081

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the prevalence and clinical characteristics of Charles Bonnet Syndrome (CBS) in patients referred for bilateral cataract surgery.

methodsThis prospective, cross-sectional clinical trial included 391 patients attending cataract assessment at a single-center tertiary cataract clinic. After clinical examination, participants were screened for presence of visual hallucinations (VHs). Participants experiencing complex VHs were further questioned regarding characteristics of their hallucinatory experiences to properly determine if they were attributable to CBS. CBS was defined as complex visual hallucinations with retained insight, no medical history or medication known to cause hallucinations and not limited to hypnagogic or hypnopompic states (hallucinations happening shortly before falling asleep and/or shortly after waking up).

resultsNineteen (4.9%) patients experienced complex VHs. Of these, 11 (2.8%) were diagnosed with CBS while 8 (2.1%) had complex hypnagogic and/or hypnopompic VHs. Multivariable logistic regression analysis identified lower best-corrected visual acuity (BCVA) in the better seeing eye as a significant predictor of CBS. When excluding participants with a BCVA>0.3, prevalence of complex VHs rose to 10.0%. Three of the patients with CBS (27.3%) had ocular comorbidities: two had exudative age-related macular degeneration (AMD), and one had drusenoid AMD. In the overall cohort, twenty-four patients (6.1%) reported prior knowledge of CBS. 

conclusionCBS was observed in a clinically relevant minority of cataract patients requiring bilateral surgical intervention. Given the high prevalence of cataract among the elderly, this study highlights the importance of healthcare personnel being aware of CBS and other complex VHs and their potential consequences for cataract patients.

Indexed as

CataractCataract ExtractionCharles Bonnet SyndromeReferral and ConsultationVisual AcuityAgedAged, 80 and overCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPrevalenceProspective StudiesCataractCataract SurgeryCharles Bonnet SyndromeVisual hallucinations

Identifiers

PMID42018151
PMCPMC13578024

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.