Evidence map›Paper›PMID 42018046›Full record

ArticleMolecular neurobiology2026

Salvianolic Acid B Inhibits Ferroptosis Through ACSL4 Pathway Regulation in sepsis-associated encephalopathy Mice.

Xingyao Li, Zhizhun Mo, Yumei Yang, Chunxia Zhao, Shuwen Zhang, Yan Lin, Yuxiang Liu, Ling Wang, Xiaolong Xu, Qingquan Liu and 1 more

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xingyao LiCollege of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Zhizhun MoShenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, 518000, China.
Yumei YangBeijing University of Chinese Medicine, Beijing, 100029, China.
Chunxia ZhaoBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Chinese Medicine, Beijing, 100010, China.
Shuwen ZhangBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Chinese Medicine, Beijing, 100010, China.
Yan LinBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Chinese Medicine, Beijing, 100010, China.
Yuxiang LiuShenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, 518000, China.
Ling WangShenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, 518000, China.
Xiaolong XuBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Chinese Medicine, Beijing, 100010, China. xiaolong_xu3013@126.com.
Qingquan LiuBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Chinese Medicine, Beijing, 100010, China. liuqingquan_2003@126.com.
Kai FanCollege of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. fan@cau.edu.cn.

Funding

National Key Research and Development Program of China 2022YFD1801102National Natural Science Foundation of China 82174348National Natural Science Foundation of China 82474428Sanming Project of Medicine in Shenzen Municipality No.SZZYSM202411012
6 · The paper itself

Abstract

Sepsis frequently leads to multi-organ injury, with the highly metabolically active nervous system being particularly vulnerable, and ferroptosis has been implicated in driving disease progression. Although Salvianolic acid B (SalB), the most abundant water-soluble active component of Salvia miltiorrhiza Bunge., has demonstrated antioxidant and anti-inflammatory properties, its specific mechanisms in sepsis-associated hippocampal injury remain unclear. To investigate SalB's therapeutic potential against sepsis and its role in mitigating neural damage via ACSL4-mediated ferroptosis, a murine sepsis model was established by cecal ligation and puncture (CLP). SalB's efficacy was evaluated using 7-day survival rates, multi-organ biochemical markers, and critical treatment windows. Inflammatory cytokines were measured by ELISA, and hippocampal morphology was examined histologically. Mechanistic studies included Fe

Indexed as

BenzofuransCoenzyme A LigasesFerroptosisSepsisSepsis-Associated EncephalopathySignal TransductionAnimalsBlood-Brain BarrierDepsidesHippocampusMaleMiceMice, Inbred C57BLAcsl4 protein, mouseBenzofuransCoenzyme A LigasesDepsidessalvianolic acid BFerroptosisNeuroinflammationSalvianolic acid BSepsisSepsis-associated encephalopathy

Identifiers

PMID42018046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.