Evidence map›Paper›PMID 42018039›Full record

ArticleCrop health2026

The MFS transporter BcTpo1 governs the oxidative stress response and infection of Botrytis cinerea.

Lingchao Wang, Youmei Xie, Jiaxuan Li, Fugen Yang, Wenxing Liang, Qianqian Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Crop health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lingchao Wang *Shandong Provincial Key Laboratory of Microbial Resource Exploration and Innovative Utilization, Engineering Research Center for Precision Pest Management for Fruits and Vegetables of Qingdao, College of Plant Health and Medicine, Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management, Qingdao Agricultural University, Qingdao, China.
Youmei Xie *Shandong Provincial Key Laboratory of Microbial Resource Exploration and Innovative Utilization, Engineering Research Center for Precision Pest Management for Fruits and Vegetables of Qingdao, College of Plant Health and Medicine, Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management, Qingdao Agricultural University, Qingdao, China.
Jiaxuan LiShandong Provincial Key Laboratory of Microbial Resource Exploration and Innovative Utilization, Engineering Research Center for Precision Pest Management for Fruits and Vegetables of Qingdao, College of Plant Health and Medicine, Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management, Qingdao Agricultural University, Qingdao, China.
Fugen YangShandong Provincial Key Laboratory of Microbial Resource Exploration and Innovative Utilization, Engineering Research Center for Precision Pest Management for Fruits and Vegetables of Qingdao, College of Plant Health and Medicine, Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management, Qingdao Agricultural University, Qingdao, China.
Wenxing LiangShandong Provincial Key Laboratory of Microbial Resource Exploration and Innovative Utilization, Engineering Research Center for Precision Pest Management for Fruits and Vegetables of Qingdao, College of Plant Health and Medicine, Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management, Qingdao Agricultural University, Qingdao, China.
Qianqian YangShandong Provincial Key Laboratory of Microbial Resource Exploration and Innovative Utilization, Engineering Research Center for Precision Pest Management for Fruits and Vegetables of Qingdao, College of Plant Health and Medicine, Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management, Qingdao Agricultural University, Qingdao, China. qyang@qau.edu.cn.ORCID http://orcid.org/0000-0001-6712-4225

Funding

Key Technology Research and Development Program of Shandong Province H20230301Ministry of Agriculture and Rural Affairs 22-1-3-9-zyyd-nshNatural Science Foundation of Shandong Province ZR2022MC195
6 · The paper itself

Abstract

Botrytis cinerea is a devastating necrotrophic pathogen causing gray mold disease. Understanding its pathogenic mechanisms is critical for developing novel control strategies. In this study, we investigated the role of spermine and its transporter BcTpo1 in fungal virulence. Spermine, but not spermidine, specifically inhibited conidial germination, infection structure formation, and pathogenicity. Deletion of BcTpo1 resulted in pleiotropic defects, including altered mycelial growth, conidiation, sclerotia formation, and melanin biosynthesis. Under oxidative stress, ΔBcTpo1 exhibited reduced intracellular spermine levels compared to the wild-type strain, correlating with elevated hydrogen peroxide sensitivity and impaired infection cushion formation. Exogenous spermine partially rescued these defects by enhancing antioxidant enzyme (superoxide dismutase and peroxidase) activities. Together, these findings establish BcTpo1 as a key regulator linking spermine homeostasis, oxidative stress adaptation, and pathogenicity.

Indexed as

Botrytis cinereaReactive oxygen species sensitivitySpermineVirulence

Identifiers

PMID42018039
PMCPMC13103187

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.