Evidence map›Paper›PMID 42018027›Full record

ReviewBiological trace element research2026

The Role of Metal Ions in Mitochondria: From Energy Metabolism to Cell Destiny.

Chunlan Li, Hongpeng Liu, Qiuyue Mao, Jing Fu, Yu Yin, Lijuan Zhu, Kunrong Li, Rui Li, Pengyue Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chunlan LiYunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, 650500, China.
Hongpeng LiuYunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, 650500, China.
Qiuyue MaoYunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, 650500, China.
Jing FuYunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, 650500, China.
Yu YinYunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, 650500, China.
Lijuan ZhuYunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, 650500, China.
Kunrong LiYunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, 650500, China.
Rui LiKunming Second People's Hospital, Kunming, Yunnan Province, 650500, China. 309670682@qq.com.
Pengyue ZhangYunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Department of Rehabilitation Medicine, The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, 650500, China. zpy19802000@163.com.

Funding

Clinical Medical Research Center in Yunnan Province 2024YNLCYXZX0286Doctoral Supervisor Team of prevention and treatment for brain diseases with acupuncture and Tuina in Yunnan Province 10170101868joint Special Project of Traditional Chinese Medicinein Science and Technology Department of Yunnan Province 202101AZ070001-256National Natural Science Foundation of China 82360977Youth Top Talent Project of 10-thousand Talent Plan in Yunnan Province YNWR-QNBJ-2018-345Yunnan province innovation team of prevention and treatment for cerebropathy with acupuncture and Tuina 202405AS350007Yunnan Provincial Department of Education Program 2025Y0639
6 · The paper itself

Abstract

Metal ions are indispensable for cellular life, as they maintain mitochondrial ion homeostasis and function as essential cofactors in mitochondrial energy metabolism, particularly within the electron transport chain (ETC) and the tricarboxylic acid (TCA) cycle. Disruption of metal ion homeostasis, however, can precipitate excessive reactive oxygen species (ROS) generation, collapse of the mitochondrial membrane potential (ΔΨm), and failure of cellular energy supply. These events ultimately culminate in mitochondrial dysfunction and trigger multiple metal ion-dependent cell death pathways, including ferroptosis, copper-induced cell death, and sodium-dependent cell death. By integrating recent advances in metallomics and mitochondrial biology, this review summarizes the roles of six key metal ions-iron (Fe

Indexed as

Energy MetabolismMetalsMitochondriaAnimalsHomeostasisHumansIonsReactive Oxygen SpeciesIonsMetalsReactive Oxygen SpeciesAdenosine triphosphateElectron transport chainMetal ionsReactive oxygen speciesTricarboxylic acid cycle

Identifiers

PMID42018027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.