Evidence map›Paper›PMID 42017691›Full record

ArticleJournal of bacteriology2026

Tyloxapol inhibits ESX-1 secretion in

Owen A Collars, Simon D Weaver, Richard L Hernandez, Matthew M Champion, Patricia A Champion

Abstract read
In one paragraph

Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Owen A CollarsDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0009-0002-1736-5770
Simon D WeaverDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0003-4354-0309
Richard L HernandezDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0009-0007-6631-5944
Matthew M ChampionDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0001-5927-5277
Patricia A ChampionDepartment of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0002-6733-596X

Funding

pH-Dependent Switching of ESX-1 Substrates in Mycobacterial PathogenesisR01AI188782 · NIAID · UNIVERSITY OF NOTRE DAME · PI Patricia A Champion · 2025 to 2026
$1.4M
NIAID NIH HHS R01 AI188782
6 · The paper itself

Abstract

Mycobacteria have a hydrophobic cell envelope that makes uniform growth in liquid culture challenging. Non-ionic detergents, including Tween-80 and tyloxapol, are commonly added to media when culturing mycobacterial species in the laboratory. Tyloxapol was reported to exhibit anti-tuberculous activity during animal infection with

Indexed as

Antigens, BacterialBacterial ProteinsMycobacterium marinumType VII Secretion SystemsAnimalsHemolysisAntigens, BacterialBacterial ProteinsType VII Secretion SystemsESX-1Mycobacterium marinumprotein secretiontyloxapol

Identifiers

PMID42017691
PMCPMC13192266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.