Evidence map›Paper›PMID 42017469›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Wireless, Adaptable and Fully Implantable Battery-powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents.

Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shahriar ShalilehSchool of Biomedical Engineering, University of British Columbia (UBC), Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0003-1933-7597
Adan MoallemiSchool of Biomedical Engineering, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Elham Mohseni VadeghaniSchool of Biomedical Engineering, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Samuel TretjakovInternational Collaborations on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.
Brianna TsuyukiSchool of Biomedical Engineering, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Alexander GolabInternational Collaborations on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.
Benjamin ReverSchool of Biomedical Engineering, University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Wolfram TetzlaffInternational Collaborations on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.
Dena ShahriariSchool of Biomedical Engineering, University of British Columbia (UBC), Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0002-3882-1977

Funding

CIHR 191895Government of Canada New Frontiers in Research Fund-Transformation NFRFT-2020-00238Michael Smith Health Research BC Scholar AwardUniversity of British Columbia Four Year Doctoral Fellowship
6 · The paper itself

Abstract

Existing technologies for optogenetic neuromodulation often rely on external power transmission or are only partially implantable, limiting their utility in mobile tissues such as the spinal cord. Here, we introduce a fully implantable, battery-powered system for light delivery to precise segments of the spinal cord in freely behaving small rodents, with operation and wireless recharging possible in any animal housing environments. Built from commercially available components with minimal in-house fabrication, the system integrates low-power electronic design, ultra-thin and flexible probes with multiple embedded microscale light-emitting diodes (µLEDs), coupled to a rechargeable battery in a modular configuration. The adaptable device can be used for optical stimulation with different wavelengths across various spinal levels with minimal system adjustments. Month-long stability as well as the device functionality were validated in small rodents. Furthermore, operator-free, targeted and transient paralysis of the hind limb was demonstrated through controlled optical stimulation of inhibitory interneurons.

Indexed as

Electric Power SuppliesOptogeneticsPhotic StimulationSpinal CordWireless TechnologyAnimalsProstheses and ImplantsRats

Identifiers

PMID42017469
PMCPMC13335532

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.