ArticleACS sensors2026
Multicompartment Drug Monitoring Reveals Paired Brain-Liver Kinetics and Selective Central Nervous System Barrier Permeability in Rats.
Article in ACS sensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Electrochemical DNA hairpin sensors for differentiating small molecule intercalation from minor groove binding.Sensors & diagnostics · 2026Article
- Pharmacokinetics and concentration-behavioral effect relationships differ between brain subcompartments.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Characterizing drug distribution to target organs is of central importance to drug discovery, especially for compounds intended to reach the central nervous system (CNS). However, the current benchmark standard measurements, based on tissue homogenate, provide limited spatial and temporal resolution. Here, we use real-time electrochemical aptamer-based (E-AB) monitoring to determine drug concentrations across specific brain regions, blood, and liver of rats after intravenous dosing. Using vancomycin and tobramycin as models, we reveal significant regional differences in brain pharmacokinetics. Vancomycin shows distinct kinetics across cortex, hippocampus, and thalamus, crossing the blood-brain barrier (BBB) but showing limited transport across the blood-cerebrospinal fluid barrier (BCSFB). Tobramycin, despite its smaller size, fails to cross either barrier. Vancomycin's liver distribution is delayed and limited, resembling its brain kinetics more than blood. These findings challenge assumptions of uniform CNS drug distribution and fast liver uptake, highlighting the need for spatially and temporally resolved pharmacokinetic assessments. Our approach enables high-resolution, in vivo profiling of drug absorption, distribution, and clearance, offering a powerful tool to inform dosing strategies and improve translational outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.