In one paragraphArticle in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Siddharth S Sivakumar *Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO (S.S.S., S.A.A., P.B., D.T.B., E.C.L., D.W.M.).ORCID 0000-0002-8621-5867 Shashank A Anand *Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO (S.S.S., S.A.A., P.B., D.T.B., E.C.L., D.W.M.).ORCID 0000-0002-6956-3624 Luke BrawerWashington University in St. Louis School of Medicine, MO (S.S.S., S.A.A., L.B.).
Rebecca L MellorDepartment of Neuroscience (R.L.M., A.B., D.W.M.), Washington University in St. Louis School of Medicine, MO.
Andreas BurkhalterDepartment of Neuroscience (R.L.M., A.B., D.W.M.), Washington University in St. Louis School of Medicine, MO.ORCID 0000-0002-5140-3657 Peter BrunnerDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO (S.S.S., S.A.A., P.B., D.T.B., E.C.L., D.W.M.).ORCID 0000-0002-2588-2754 David T BundyDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO (S.S.S., S.A.A., P.B., D.T.B., E.C.L., D.W.M.).ORCID 0000-0001-6491-044X Eric C LeuthardtDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO (S.S.S., S.A.A., P.B., D.T.B., E.C.L., D.W.M.).
Daniel W MoranDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO (S.S.S., S.A.A., P.B., D.T.B., E.C.L., D.W.M.).ORCID 0000-0002-7503-565X Funding
Training and DisseminationP41EB018783 · NIBIB · WADSWORTH CENTER · PI Yi Chen · 2014 to 2026
$15.4MAn Ecosystem of Technology and Protocols for Adaptive Neuromodulation Research in HumansU01NS128612 · NINDS · MAYO CLINIC ROCHESTER · PI Peter Brunner, Kai Miller · 2022 to 2026
$4.5MDevelopment of a Micro-ECoG Neuroprosthesis for Motor Rehabilitation in a Chronic Corticospinal Stroke InjuryR01NS101013 · NINDS · WASHINGTON UNIVERSITY · PI LEUTHARDT, ERIC CLAUDE, MORAN, DANIEL WILLIAM · 2018 to 2022
$2.9MBCI2000: Software Resource for Adaptive Neurotechnology ResearchU24NS109103 · NINDS · WASHINGTON UNIVERSITY · PI BRUNNER, PETER · 2019 to 2024
$2.8MInterdisciplinary Training in Cognitive, Computational and Systems Neuroscience (CCSN)T32NS115672 · NINDS · WASHINGTON UNIVERSITY · PI TODD S BRAVER, Camillo Padoa-Schioppa · 2020 to 2026
$1.8MBCI2000+: A Software Platform for Adaptive NeurotechnologiesR01EB026439 · NIBIB · WASHINGTON UNIVERSITY · PI BRUNNER, PETER · 2018 to 2022
$1.5MOptimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEGUH3NS123066 · NINDS · MAYO CLINIC ROCHESTER · PI Benjamin H Brinkmann, Gregory A Worrell · 2025 to 2026
$1.4MTranslational Neuroscience and Neurotechnology Training (TNNT)T32NS126157 · NINDS · WASHINGTON UNIVERSITY · PI Daniel William Moran · 2022 to 2026
$776kFunctional connectivity associated with motor recovery after internal capsule lesionsF31NS124104 · NINDS · WASHINGTON UNIVERSITY · PI ANAND, SHASHANK AMIT · 2022 to 2023
$94kNIBIB NIH HHS P41 EB018783NIBIB NIH HHS R01 EB026439NINDS NIH HHS F31 NS124104NINDS NIH HHS R01 NS101013NINDS NIH HHS T32 NS115672NINDS NIH HHS T32 NS126157NINDS NIH HHS U01 NS128612NINDS NIH HHS U24 NS109103NINDS NIH HHS UH3 NS123066
6 · The paper itselfAbstract
backgroundLoss of hand control is a major source of poststroke disability, particularly when infarcts involve subcortical white matter. Yet, most preclinical models target the cortex and infer recovery from task performance without quantifying whether improvements reflect restoration or adaptation. To address this, we developed a novel nonhuman primate model of focal internal capsule infarct. This study is exploratory and hypothesis-testing, including prespecified hypotheses regarding motor impairment and adaptation.
methodsThree adult male rhesus macaques (
resultsMagnetic resonance imaging and histology confirmed focal infarcts centered on the posterior limb of the internal capsule, with variable volumes. All animals significantly reduced contralesional hand use post-infarct (Fisher exact test; all
conclusionsThis model recapitulates key features of human subcortical stroke, including persistent distal motor deficits, shifts in hand preference, systematic motor adaptation, and interindividual variability, establishing a translationally oriented platform for studying stroke mechanisms and evaluating recovery-promoting interventions.
Indexed as
Adaptation, PhysiologicalCerebral InfarctionInternal CapsuleAnimalsDisease Models, AnimalEndothelin-1Macaca mulattaMagnetic Resonance ImagingMaleEndothelin-1endothelin-1forelimbinternal capsuleischemic strokeMacaca mulattamotor skillswhite matter
Identifiers
PMID42017256
PMCPMC13135776
What OpenQuestion holds
Textmetadata
LicenceTDM
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