Evidence map›Paper›PMID 42017158›Full record

ArticleRSC advances2026

Surface-confined FRET nanoplatform printed

Stefania Carbone, Simone Russo, Anna Palma, Giuseppe Junior Mosca, Sara La Manna, Alessia Cugudda, Sara Coppola, Pier Luca Maffettone, Simonetta Grilli, Giuseppe Vitiello and 1 more

Abstract read
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In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stefania CarboneDepartment of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II Piazzale Tecchio 80 80125 Naples Italy giuseppe.vitiello@unina.it concetta.dinatale@unina.it.
Simone RussoDepartment of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II Piazzale Tecchio 80 80125 Naples Italy giuseppe.vitiello@unina.it concetta.dinatale@unina.it.ORCID https://orcid.org/0009-0009-6109-7372
Anna PalmaDepartment of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II Piazzale Tecchio 80 80125 Naples Italy giuseppe.vitiello@unina.it concetta.dinatale@unina.it.
Giuseppe Junior MoscaDepartment of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II Piazzale Tecchio 80 80125 Naples Italy giuseppe.vitiello@unina.it concetta.dinatale@unina.it.
Sara La MannaDepartment of Pharmacy, University of Naples Federico II 80131 Naples Italy.
Alessia CuguddaDepartment of Pharmacy, University of Naples Federico II 80131 Naples Italy.
Sara CoppolaInstitute of Applied Sciences and Intelligent Systems (ISASI), National Research Council of Italy (CNR) Pozzuoli NA 80078 Italy simonetta.grilli@cnr.it.
Pier Luca MaffettoneDepartment of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II Piazzale Tecchio 80 80125 Naples Italy giuseppe.vitiello@unina.it concetta.dinatale@unina.it.
Simonetta GrilliInstitute of Applied Sciences and Intelligent Systems (ISASI), National Research Council of Italy (CNR) Pozzuoli NA 80078 Italy simonetta.grilli@cnr.it.
Giuseppe VitielloDepartment of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II Piazzale Tecchio 80 80125 Naples Italy giuseppe.vitiello@unina.it concetta.dinatale@unina.it.ORCID https://orcid.org/0000-0003-3389-6942
Concetta Di NataleDepartment of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II Piazzale Tecchio 80 80125 Naples Italy giuseppe.vitiello@unina.it concetta.dinatale@unina.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The detection of protein biomarkers at low concentrations through fluorescence resonance energy transfer (FRET) remains challenging, as conventional homogeneous assays are often affected by uncontrolled donor-acceptor diffusion, fluorophore quenching, and limited reproducibility. In this work, we propose a two-dimensional solid-supported FRET nanoplatform enabling a surface-confined sensing strategy for the stable and reliable detection of the model biomarker Tumor Necrosis Factor-alpha (TNF-α). The approach combines a nanostructured film of fluorine-doped ZnO (F/ZnO) quantum dots deposited on a glass slide with a high-precision pyro-electrohydrodynamic jet (p-jet) printing technique. Microspots of a high-affinity peptide (P52) were printed onto the F/ZnO layer to control donor-acceptor spacing and optimize fluorophore orientation and density, ensuring efficient FRET and reduced variability between samples. The platform provides stable, reproducible, and concentration-dependent FRET signals in the ng mL

Identifiers

PMID42017158
PMCPMC13093259

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.