ArticleCureus2026
Clinical Characteristics and Predictors of Chronicity in Children With Immune Thrombocytopenia.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Preliminary experience with oral thrombopoietin-receptor agonists, primarily hetrombopag, in pediatric immune thrombocytopenia: a pilot single-center retrospective report.Translational pediatrics · 2026Article
- Correlation between the CD8Frontiers in pediatrics · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Immune thrombocytopenia (ITP) in children is typically self-limited; however, a subset progresses to chronic disease. Identifying early predictors of chronic evolution remains clinically important to improve risk stratification and management strategies. Methods We conducted a retrospective cohort study of 47 children aged 1-14 years diagnosed with primary ITP at a tertiary care center between 2020 and 2025. Baseline demographic, clinical, laboratory, and treatment data were extracted from electronic records. Early treatment response was categorized as complete, partial, transient, or no response. Associations with chronic disease were evaluated using non-parametric testing and exact categorical analyses. Multivariable logistic regression was performed to identify independent predictors of chronicity. Results Chronic ITP developed in 12 of 47 patients (25.5%). The early response category was strongly associated with chronic evolution (p < 0.001). Among chronic patients, 91.7% exhibited a transient response pattern, and none achieved a sustained complete response. Baseline platelet count differed significantly between complete and non-complete responders (p = 0.002) and showed a near-significant association with chronicity in multivariable analysis (adjusted OR 1.057 per 1 ×10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.